Analysis of erosive outcome (erosions, yes/no) at five years for the whole dataset and in a subset satisfying ACR criteria for rheumatoid arthritis by five years
| SNP genotype | Inflammatory arthritis | ACR criteria positive RA patients | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Erosive (%), n = 194 | Non-erosive (%), n = 244 | OR (95% CI)† | Erosive (%), n = 174 | Non-erosive (%), n = 143 | OR (95% CI)† | |||||||
| *The PADI4 susceptibility haplotype, as defined in the Japanese population, was referred to as 2 and all other haplotypes as 1. | ||||||||||||
| †Odds ratio and 95% confidence intervals of erosive change by five years compared with wild type genotype. | ||||||||||||
| CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis; SNP, single nucleotide polymorphism. | ||||||||||||
| Padi4_89 | ||||||||||||
| GG | 70 (37.8) | 79 (33.9) | 63 (36.6) | 50 (35.7) | ||||||||
| GA | 86 (46.5) | 115 (49.4) | 0.84 (0.5 to 1.3) | 80 (46.5) | 64 (45.7) | 0.99 (0.6 to 1.7) | ||||||
| AA | 29 (15.7) | 39 (16.7) | 0.84 (0.5 to 1.6) | 29 (16.9) | 26 (18.6) | 0.86 (0.4 to 1.8) | ||||||
| Comparison | p = 0.71 | p = 0.93 | ||||||||||
| Padi4_90 | ||||||||||||
| TT | 63 (35.6) | 77 (33.6) | 59 (35.5) | 48 (35.0) | ||||||||
| TC | 83 (46.9) | 111 (48.5) | 0.91 (0.6 to 1.5) | 77 (46.4) | 63 (46.0) | 0.99 (0.6 to 1.7) | ||||||
| CC | 31 (17.5) | 41 (17.9) | 0.92 (0.5 to 1.7) | 30 (18.1) | 26 (19.0) | 0.94 (0.5 to 1.9) | ||||||
| Comparison | p = 0.92 | p = 0.98 | ||||||||||
| Padi4_92 | ||||||||||||
| GG | 57 (31.2) | 73 (31.6) | 52 (30.4) | 46 (32.9) | ||||||||
| GC | 91 (49.7) | 113 (48.9) | 1.03 (0.6 to 1.6) | 86 (50.3) | 66 (47.1) | 1.15 (0.7 to 2.0) | ||||||
| CC | 35 (19.1) | 45 (19.5) | 0.99 (0.5 to 1.8) | 33 (19.3) | 28 (20.0) | 1.02 (0.5 to 2.1) | ||||||
| Comparison | p = 0.99 | p = 0.83 | ||||||||||
| Padi4_104 | ||||||||||||
| TT | 85 (45.5) | 112 (47.7) | 77 (44.3) | 67 (46.9) | ||||||||
| TC | 83 (44.4) | 96 (40.8) | 1.14 (0.7 to 1.7) | 78 (44.8) | 59 (41.2) | 1.15 (0.7 to 1.9) | ||||||
| CC | 19 (10.1) | 27 (11.5) | 0.93 (0.5 to 1.9) | 19 (10.9) | 17 (11.9) | 0.97 (0.4 to 2.2) | ||||||
| Comparison | p = 0.75 | p = 0.81 | ||||||||||
| Haplotype* | ||||||||||||
| 1/1 | 83 (45.9) | 111 (48.3) | 76 (45.0) | 65 (46.8) | ||||||||
| ½ | 79 (43.6) | 92 (40.0) | 1.15 (0.7 to 1.8) | 74 (43.8) | 57 (41.0) | 1.11 (0.7 to 1.8) | ||||||
| 2/2 | 19 (10.5) | 27 (11.7) | 0.94 (0.5 to 1.9) | 19 (11.2) | 17 (12.2) | 0.96 (0.4 to 2.1) | ||||||
| Comparison | p = 0.75 | p = 0.88 | ||||||||||