Clinical manifestations at the time of presentation with catastrophic antiphospholipid syndrome in patients from the CAPS registry
| Feature | n (%) |
|---|---|
| RDS, respiratory distress syndrome. | |
| Peripheral thrombosis | 74 (34) |
| Deep vein thrombosis | 50 (23) |
| Femoral artery | 8 (4) |
| Radial artery | 4 (2) |
| Other arteries | 19 (9) |
| Cerebral | 133 (60) |
| Infarcts | 97 (44) |
| Encephalopathy | 17 (8) |
| Seizures | 13 (6) |
| Microthrombosis | 10 (5) |
| Venous cerebral thrombosis | 5 (2) |
| Coma | 4 (2) |
| Transient ischaemic attack | 2 (1) |
| Cardiac | 115 (52) |
| Valve lesion | 56 (26) |
| Myocardial infarction | 50 (23) |
| Heart failure | 22 (10) |
| Microthrombosis | 10 (5) |
| Mural thrombi | 9 (4) |
| Pulmonary | 146 (66) |
| Acute RDS | 74 (34) |
| Pulmonary embolism | 54 (24) |
| Pulmonary haemorrhage | 16 (7) |
| Microthrombosis | 10 (5) |
| Pulmonary oedema | 7 (3) |
| Infarction | 6 (3) |
| Abdominal | 189 (86) |
| Renal | 154 (70) |
| Hepatic | 62 (28) |
| Splenic | 41 (19) |
| Adrenal | 33 (15) |
| Intestinal | 27 (12) |
| Mesenteric | 23 (11) |
| Pancreas | 21 (10) |
| Portal vein thrombosis | 7 (3) |
| Inferior cava thrombosis | 7 (3) |
| Gallbladder thrombosis | 6 (3) |
| Skin | 104 (47) |
| Livedo reticularis | 62 (28) |
| Skin ulcers | 30 (14) |
| Digital ischaemia | 21 (10) |
| Purpura | 12 (6) |
| Necrosis | 7 (3) |
| Microthrombosis | 7 (3) |
| Splinter haemorrhages | 5 (2) |
| Other manifestations | 56 (25) |
| Retinal artery thrombosis | 11 (5) |
| Bone marrow necrosis | 7 (3) |
| Uterus | 7 (3) |
| Neuropathy | 7 (3) |
| Testicles | 4 (2) |
| Retinal vein thrombosis | 4 (2) |
| Thyroid thrombosis | 3 (1) |
| Avascular necrosis | 4 (2) |
| Others | 8 (4) |