Sensitivity, specificity, and positive predictive value (PPV) of ACF, anti-CCP, and IgM-RF for the clinical diagnosis of rheumatoid arthritis in early arthritis
| Sensitivity (%) | Specificity (%) | PPV (%) | |
|---|---|---|---|
| ACF, antibodies to citrullinated human fibrinogen; CCP, cyclic citrullinated peptide; RF, rheumatoid factor; ROC, receiver operating characteristic. | |||
| Early arthritis (n = 379) | |||
| IgM-RF ⩾45 | 44.6 | 96.7 | 96.6 |
| ACF ⩾140 | 55.8 | 92.6 | 94.1 |
| Anti-CCP ⩾25 | 57.8 | 94.2 | 95.5 |
| IgM-RF negative early arthritis (n = 260) | |||
| ACF ⩾140 | 28.7 | 94.9 | 87.2 |
| Anti-CCP ⩾25 | 30.8 | 96.6 | 91.7 |