Renal disease, SLE activity, and damage scores under extended IAS
| Start of IAS (n = 11) | 3 mo IAS (n = 11) | 6 mo IAS (n = 11) | 12 mo IAS (n = 11) | p Value | |
|---|---|---|---|---|---|
| Normal ranges are provided in table 2. Data are analysed by one way analysis of variance. | |||||
| Results are shown as mean (SD) unless stated otherwise. | |||||
| Renal function | |||||
| Proteinuria (g/day) | 6.7 (4.6) | 4.3 (3.5) | 2.5 (2.5) | 2.9 (2.4) | <0.001 |
| R20/R50 (%) | – | 55/45 | 91/64 | 82/64 | |
| Serum albumin (g/l) | 26.3 (5.8) | 29.5 (6.0) | 33.2 (7.1) | 35.0 (8.3) | <0.0001 |
| Creatinine clearance (ml/min) | 58.6 (33.8) | 76.5 (46.1) | 74.5 (28.3) | 67.0 (33.0) | NS |
| Serum creatinine (μmol/l) | 145 (75) | 120 (50) | 120 (35) | 125 (60) | NS |
| SLE activity | |||||
| SIS | 15 (5) | 5 (2) | 4 (1) | 5 (2) | <0.0001 |
| R20/R50 (%) | - | 100/82 | 100/91 | 100/73 | |
| SLEDAI | 21 (7) | 5 (4) | 4 (3) | 5 (4) | <0.0001 |
| ECLAM | 7 (2) | 2 (1) | 2 (1) | 3 (1) | <0.0001 |
| Anti-dsDNA (IU/ml) | 391 (647) | 146 (218) | 77 (78) | 53 (50) | 0.0002 |
| R20/R50 (%) | - | 82/82 | 91/64 | 91/64 | |
| C3c (g/l) | 0.5 (0.1) | 0.8 (0.2) | 0.9 (0.1) | 0.8 (0.2) | <0.002 |
| C4 (g/l) | 0.1 (0.05) | 0.2 (0.09) | 0.2 (0.06) | 0.2 (0.06) | <0.0001 |
| SLE damage (SLICC/ACR) | 1.3 (0.8) | 1.3 (0.9) | 1.2 (1.0) | NS | |
| IAS frequency (sessions/week) | – | 1.3 (0.4) | 1.0 (0.2) | 0.9 (0.2) | |