Table 8

How often have you encountered these adverse events that you ascribed to a tumour necrosis factor (TNF) inhibitor? (US rheumatologists online survey, April 2005)

Adverse event	Never seen (%)	1–3 cases (%)	Calculated total events	Event risk per patient (%)
Pneumonia	19	42	2720	2.28
Herpes zoster	35	45	1847	1.55
Sepsis	42	45	1436	1.21
PPD positivity	56	30	1340	1.13
Tuberculosis	78	21	423	0.36
Systemic fungal	76	23	450	0.38
Cytopenia	48	42	1315	1.10
Demyelinating disorder	74	25	463	0.39
Drug induced lupus	56	37	1038	0.87
Vasculitis	76	21	518	0.43
Heart failure	61	33	841	0.71
>3-fold increase hepatic enzymes	74	21	608	0.51
Hepatic failure	97	2	61	0.05
Lymphoma	76	22	426	0.36
Leukaemia	97	3	93	0.08
Solid tumor	69	25	787	0.66
Pregnancy on TNF inhibitor	77	21	493	0.41
Bronchospasm	68	24	906	0.76
Hypotension	55	31	1374	1.15
Severe skin reaction	42	42	1593	1.34
Cardiac arrest	98	2	40	0.03