Table 3

 Factors that most influence the decision to use a TNF inhibitor*

Response (mean)
*Respondents were asked to rank these on a scale of 1–5 from most influential (1) to least or never influential (5) (n = 953). (Online survey, US rheumatologists, April 2005.)
Failure of methotrexate1.46
Failure of multiple (>2) disease modifying antirheumatic drugs (DMARDs)1.50
Physician global assessment1.56
Radiographic erosions or worsening1.58
Functional impairment1.59
Extra-articular manifestations2.38
Published guidelines2.56
Formulary restrictions2.67
Patient request2.82
Managed care guidelines3.24
Director consumer advertising4.34