Continuation of treatment with biological agents
| n | Treatment continuation after 6 months | Treatment continuation after 12 months | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Adverse events* | Lack of efficacy† | Total | Adverse events* | Lack of efficacy† | ||||||||||||||||||
| Values are percentages with 95% confidence intervals in parentheses. | |||||||||||||||||||||||
| *Only includes termination because of adverse events. | |||||||||||||||||||||||
| ‡Only includes termination because of lack of efficacy. | |||||||||||||||||||||||
| DMARD, disease modifying antirheumatic drug. | |||||||||||||||||||||||
| Etanercept | |||||||||||||||||||||||
| alone | 254 | 71.2 | (62.7 to 79.7) | 90.8 | (83.5 to 98.1) | 81.4 | (73.5 to 89.2) | 64.4 | (55.4 to 73.4) | 86.1 | (78.4 to 93.7) | 80.1 | (72.2 to 88.0) | ||||||||||
| +methotrexate | 167 | 82.3 | (72.2 to 92.5) | 91.4 | (82.9 to 100) | 89.5 | (80.2 to 98.9) | 71.6 | (60.9 to 82.3) | 86.7 | (77.9 to 95.5) | 83.1 | (73.4 to 92.8) | ||||||||||
| +other DMARD | 90 | 84.0 | (71.8 to 96.2) | 92.3 | (85.9 to 98.7) | 92.0 | (81.0 to 100) | 74.9 | (61.8 to 87.9) | 92.3 | (85.9 to 98.7) | 85.6 | (73.9 to 97.2) | ||||||||||
| total | 511 | 77.2 | (71.0 to 83.3) | 91.3 | (86.3 to 96.2) | 86.0 | (79.8 to 92.1) | 68.6 | (62.1 to 75.1) | 87.4 | (82.3 to 92.5) | 82.0 | (75.6 to 88.3) | ||||||||||
| Infliximab | |||||||||||||||||||||||
| alone | 36 | 67.1 | (44.0 to 90.3) | 83.2 | (63.3 to 100) | 77.7 | (54.5 to 100) | 44.2 | (15.9 to 72.5) | 73.0 | (51.1 to 94.9) | 55.0 | (24.9 to 85.2) | ||||||||||
| +methotrexate | 219 | 77.0 | (68.6 to 85.4) | 85.5 | (78.5 to 92.6) | 90.3 | (83.2 to 97.3) | 66.2 | (57.4 to 75.1) | 81.8 | (74.5 to 89.1) | 82.1 | (74.6 to 89.5) | ||||||||||
| +other DMARD | 88 | 80.1 | (65.6 to 94.6) | 90.1 | (76.8 to 100) | 87.9 | (73.7 to 100) | 72.1 | (56.5 to 87.6) | 83.4 | (69.1 to 97.6) | 85.5 | (70.9 to 100) | ||||||||||
| total | 343 | 76.7 | (69.5 to 83.8) | 86.4 | (80.0 to 92.8) | 88.3 | (81.8 to 94.8) | 65.4 | (57.7 to 73.0) | 81.3 | (74.6 to 88.0) | 80.2 | (73.3 to 87.2) | ||||||||||
| Anakinra | |||||||||||||||||||||||
| total | 70 | 66.2 | (49.5 to 83.0) | 83.7 | (74.3 to 93.2) | 79.1 | (62.0 to 96.2) | 59.0 | (41.0 to 77.0) | 83.7 | (74.3 to 93.2) | 70.4 | (51.6 to 89.3) | ||||||||||