Table 1

 Currently identified proteolytic fragments and cleavages sites obtained by in vitro degradation of native* or recombinant† SAA are compared with AA amyloid proteins extracted from human tissue. Very few of the fragments generated thus far in vitro correspond with the 18 naturally occurring AA amyloid proteins identified until now

ProteaseProteolytic fragmentsFragments corresponding to naturally occurring AA amyloid proteins No (%)Ref
‡A fragment of 2726.5 Da created by MMP-1 corresponded to either Leu7 to Tyr29, Gly8 to Ile30, or Glu9 to Gly31.
MMP-1* ‡Arg1 to Ala570/184
Ile58 to Tyr104
Leu7 to Tyr29, Gly8 to Ile30 or Glu9 to Gly31
MMP-2*Arg1 to Gly510/184
Val52 to Tyr104
Trp8 to Ala55
MMP-3*Gly8 to Ala550/184
Ser2 to Ala57
Ser2 to Glu56
Ser2 to Gly51
Ala57 to Tyr104
Ile58 to Tyr104
Glu74 to Tyr104
CathB†Ser76 to Leu772/18 (11)14
Asn83 to Glu84
CathB†(see figs 3 and 5)9/18 (50)Present study
CathL†(see figs 3 and 5)0/18Present study
Cleavage sites
CathD†Phe6–Leu70/1817
Glu9–Ala10
Asp12–Gly13
Arg15–Asp16
Ala20–Tyr21
Ala27–Asn28
Asn28–Tyr29
Elastase†Ala27–Asn281/18 (6)14
Ile58–Ser59
Ile65–Gln66