Table 3

 Allele frequencies of the three variants of the CARD15 gene in patients and controls after stratification for the PSORS1 associated HCR haplotype HCR*WWCC and results of χ2 statistics (compared with controls)

PolymorphismControlsPsoriasis vulgarisPsoriatic arthritis
n (%)n (%)χ2p Valuen (%)χ2p Value
mut, mutant allele; wt, wild type allele.
HCR*WWCC positive
R702Wwt231 (91)356 (96)5.8390.016370 (94)2.8190.093
mut23 (9)16 (4)22 (6)
G908Rwt252 (98)357 (99)0.0340.853385 (98)0.0460.830
mut4 (2)5 (1)7 (2)
leu1007fsinsCwt249 (97)365 (98)0.0660.797383 (98)0.6430.422
mut7 (3)9 (2)7 (2)
HCR*WWCC negative
R702Wwt431 (95)177 (94)0.1630.686321 (94)0.4310.511
mut23 (5)11 (6)21 (6)
G908Rwt454 (97)187 (99)2.870.09337 (98)0.2520.616
mut12 (3)1 (1)7 (2)
leu1007fsinsCwt464 (97)184 (98)0.6760.411333 (96)0.5340.465
mut16 (3)4 (2)15 (4)