Table 2

 Analysis of the haplotypes: comparison of frequency of transmitted alleles and non-transmitted alleles and TDT test

Haplotypes with a frequency >5%AFBACTDT
RS188_1RS188_2PADI4_92PADI4_96PADI4_102Freq transmFreq untransmχ2TransmittedUntransmittedp Value
*Cumulative rate.
AFBAC, affected family based controls; AhFibA, anti-human fibrin(ogen) autoantibodies; CCP, cyclic citrullinated peptides; freq transm, frequency transmitted; freq untransm, frequency untransmitted; GRR, genotype relative risk; RA, rheumatoid arthritis; TDT, transmission disequilibrium test.
(A) In 100 white RA families
Haplotype 1CCCTC0.0550.0750.6210140.1
Haplotype 2CCGCT0.0250.0552.255110.13
Haplotype 3CCGCC0.1950.1750.2231270.6
Haplotype 4CCGTC0.0450.0600.439120.51
Haplotype 5CGCTC0.1650.112.228170.1
Haplotype 6TGCTC0.3350.340.007437380.91
Japanese “susceptible” haplotype
Haplotype 3CC G C C
Haplotype 7TC G C C 0.220*0.220*036361
Haplotype 8CG G C C
(B) In families with anti-CCP+ RA cases
Haplotype 1CCCTC0.0770.0560.471070.47
Haplotype 2CCGCT0.0280.0631.92490.17
Haplotype 3CC G C C 0.2110.1620.9225180.29
Haplotype 4CCGTC0.0490.0770.897110.35
Haplotype 5CGCTC0.1270.127015151
Haplotype 6TGCTC0.3520.3450.0128270.9
Japanese “susceptible” haplotype
Haplotype 3CC G C C 0.246*0.212*0.4636250.16
Haplotype 7TC G C C
Haplotype 8CG G C C
(C) In families with AhFibA+ RA cases
Haplotype 1CCCTC0.0790.0630.22970.62
Haplotype 2CCGCT0.0240.0632.27380.13
Haplotype 3CC G C C 0.2140.1900.1722190.64
Haplotype 4CCGTC0.0400.0872.255110.13
Haplotype 5CGCTC0.1270.1350.0313140.85
Haplotype 6TGCTC0.3330.3020.2025210.56
Japanese “susceptible” haplotype
Haplotype 3CC G C C
Haplotype 7TC G C C 0.246*0.198*0.8326200.38
Haplotype 8CG G C C