Table 1

 Analysis of the single nucleotide polymorphisms: comparison of the frequency of transmitted and non-transmitted alleles, TDT, and GRR tests

SNP alleleAllele frequenciesTDTGRR
Freq transmFreq untransmp ValueTransmUntransmp Valuep Value
AhFibA, anti-human fibrin(ogen) autoantibodies; CCP, cyclic citrullinated peptides; freq transm, frequency transmitted; freq untransm, frequency untransmitted; GRR, genotype relative risk; RA, rheumatoid arthritis; TDT, transmission disequilibrium test; transm, transmitted; untransm, untransmitted.
(A) In 100 RA families
RS188_1C0.5450.5300.7653500.770.24
RS188_1T0.4550.47050530.77
RS188_2C0.8000.8650.0821340.080.22
RS188_2G0.2000.13534210.08
PADI4_92C0.6200.5800.4151430.410.63
PADI4_92G0.3800.42043510.41
PADI4_96C0.3210.3470.5939440.580.52
PADI4_96T0.6790.65344390.58
PADI4_102T0.0760.0810.8514150.850.60
PADI4_102C0.9240.91915140.85
(B) In families with anti-CCP+ RA cases
RS188_1C0.5560.5350.7236330.720.44
RS188_1T0.4440.46533360.72
RS188_2C0.8310.8450.7418200.750.67
RS188_2G0.1690.15520180.75
PADI4_92C0.6200.5850.5438330.550.08
PADI4_92G0.3800.41533380.55
PADI4_96C0.3260.3410.8030320.800.69
PADI4_96T0.6740.65932300.80
PADI4_102T0.0640.0790.648100.640.59
PADI4_102C0.9360.9211080.64
(C) In families with AhFibA+ RA cases
RS188_1C0.5480.5870.5229340.530.57
RS188_1T0.4520.41334290.53
RS188_2C0.8330.8410.8617180.870.89
RS188_2G0.1670.15918170.87
PADI4_92C0.6110.5630.4435290.450.35
PADI4_92G0.3890.43729350.45
PADI4_96C0.3360.3440.8928290.890.85
PADI4_96T0.6640.65629280.89
PADI4_102T0.0730.07319910.59
PADI4_102C0.9270.927991