Table 2

 Differential diagnosis of multiorgan thrombotic disorders

Catastrophic APSDICTMHA
*In cases of familial thrombocytopenic purpura (TTP), acquired idiopathic TTP, and pregnancy related TTP.
ADAMTS-13, von Willebrand factor cleaving protease; APS, antiphospholipid syndrome; DIC, disseminated intravascular coagulation; TMHA, thrombotic microangiopathic haemolytic anaemia.
Haemorrhagic manifestations+±
Anaemia±±+
Schistocytes±±++
Thrombocytopenia+++++++
Prolonged prothrombin time+
Prolonged activated partial thromboplastin time±+
Fibrinogen degradation products±+
Antiphospholipid antibodies++±±
Plasma ADAMTS-13 activityNormal?Moderately reducedAbsent* or severely reduced