Table 1

 Prevalence of CARD15 variants in the populations according to subtypes defined at baseline

nCarriers of CARD15 variant(s)
2: p<0.001 (carrier frequency in Crohn’s disease v control population).
†χ2: p = 0.5 (carrier frequency in general spondyloarthropathies v control population).
‡χ2: p = 0.001 (chronic inflammation in patients with CARD15 variant v chronic inflammation in patients without CARD15 polymorphism).
Controls14024 (17%)
Crohn’s disease15677 (49%)*
Spondyloarthropathy10421 (20%)†
    Ankylosing spondylitis7516 (21%)
    Undifferentiated spondyloarthropathies295 (17%)
Gut histology in the spondyloarthropathy population
Chronic inflammation40 (38%)15 (38%)‡
Acute inflammation24 (23%)0 (0%)
Normal histology40 (38%)6 (15%)