Cytokine gene polymorphism frequency in patients with Wegener’s granulomatosis and controls
| Genotype | Phenotype | Patients (n = 32) | Controls (n = 91) |
|---|---|---|---|
| *p = 0.027, pc = 0.054; OR = 3.14 (95% CI, 1.23 to 8.01), power 46%. | |||
| †p = 0.029, pc = 0.058; OR = 5.01 (95% CI, 1.31 to 19.14), power 40.5%. | |||
| CI, confidence interval; IFNγ, interferon γ; IL, interleukin; OR, odds ratio; TGFβ1, transforming growth factor β1; TNFα, tumour necrosis factor α. | |||
| IFNγ intron +874 (A/T) | |||
| T/T | High | 11 (34)* | 13 (14) |
| T/A | Intermediate | 14 (44) | 53 (58) |
| A/A | Low | 7 (22) | 25 (28) |
| TGFβ1 codon 10 (T/C)/25 (C/G) | |||
| T/T G/G | High | 6 (19) | 21 (23) |
| T/C G/G | High | 13 (41) | 44 (48) |
| T/C G/C | Intermediate | 3 (9) | 7 (8) |
| C/C G/G | Intermediate | 6 (19) | 14 (15) |
| T/T G/C | Intermediate | 1 (3) | / |
| C/C G/C | Low | 2 (6) | 4 (4) |
| C/C C/C | Low | 1 (3) | 1 (1) |
| T/T C/C | Low | / | / |
| T/C C/C | Low | / | / |
| IL6 promotor −174 (C/G) | |||
| G/G | High | 14 (44) | 27 (30) |
| G/C | High | 14 (44) | 52 (57) |
| C/C | Low | 4 (13) | 12 (13) |
| IL10 promotor −1082 (G/A), −819 (C/T), −592 (C/A) | |||
| GCC/GCC | High | 6 (19) | 19 (21) |
| GCC/ACC | Intermediate | 11 (34) | 27 (30) |
| GCC/ATA | Intermediate | 11 (34) | 24 (26) |
| ACC/ACC | Low | 1 (3) | 10 (11) |
| ACC/ATA | Low | 3 (9) | 9 (10) |
| ATA/ATA | Low | / | 2 (2) |
| TNFα promotor −376 (G/A), −308 (G/A), −238 (G/A) | |||
| −376 G/G | Intermediate | 30 (94) | 89 (98) |
| −376 G/A | Intermediate | 2 (6) | 2 (2) |
| −376 A/A | Intermediate | / | / |
| −308 G/G | Low | 24 (75) | 79 (87) |
| −308 G/A | High | 6 (19) | 10 (11) |
| −308 A/A | High | 2 (6) | 2 (2) |
| −238 G/G | Low | 26 (81) | 87 (96) |
| −238 G/A | High | 6 (19)† | 4 (4) |
| −238 A/A | High | / | / |