Cytokine gene polymorphism frequency in patients with Wegener’s granulomatosis and controls
Genotype | Phenotype | Patients (n = 32) | Controls (n = 91) |
---|---|---|---|
*p = 0.027, pc = 0.054; OR = 3.14 (95% CI, 1.23 to 8.01), power 46%. | |||
†p = 0.029, pc = 0.058; OR = 5.01 (95% CI, 1.31 to 19.14), power 40.5%. | |||
CI, confidence interval; IFNγ, interferon γ; IL, interleukin; OR, odds ratio; TGFβ1, transforming growth factor β1; TNFα, tumour necrosis factor α. | |||
IFNγ intron +874 (A/T) | |||
T/T | High | 11 (34)* | 13 (14) |
T/A | Intermediate | 14 (44) | 53 (58) |
A/A | Low | 7 (22) | 25 (28) |
TGFβ1 codon 10 (T/C)/25 (C/G) | |||
T/T G/G | High | 6 (19) | 21 (23) |
T/C G/G | High | 13 (41) | 44 (48) |
T/C G/C | Intermediate | 3 (9) | 7 (8) |
C/C G/G | Intermediate | 6 (19) | 14 (15) |
T/T G/C | Intermediate | 1 (3) | / |
C/C G/C | Low | 2 (6) | 4 (4) |
C/C C/C | Low | 1 (3) | 1 (1) |
T/T C/C | Low | / | / |
T/C C/C | Low | / | / |
IL6 promotor −174 (C/G) | |||
G/G | High | 14 (44) | 27 (30) |
G/C | High | 14 (44) | 52 (57) |
C/C | Low | 4 (13) | 12 (13) |
IL10 promotor −1082 (G/A), −819 (C/T), −592 (C/A) | |||
GCC/GCC | High | 6 (19) | 19 (21) |
GCC/ACC | Intermediate | 11 (34) | 27 (30) |
GCC/ATA | Intermediate | 11 (34) | 24 (26) |
ACC/ACC | Low | 1 (3) | 10 (11) |
ACC/ATA | Low | 3 (9) | 9 (10) |
ATA/ATA | Low | / | 2 (2) |
TNFα promotor −376 (G/A), −308 (G/A), −238 (G/A) | |||
−376 G/G | Intermediate | 30 (94) | 89 (98) |
−376 G/A | Intermediate | 2 (6) | 2 (2) |
−376 A/A | Intermediate | / | / |
−308 G/G | Low | 24 (75) | 79 (87) |
−308 G/A | High | 6 (19) | 10 (11) |
−308 A/A | High | 2 (6) | 2 (2) |
−238 G/G | Low | 26 (81) | 87 (96) |
−238 G/A | High | 6 (19)† | 4 (4) |
−238 A/A | High | / | / |