Stratification of patients with Wegener’s granulomatosis defined by end stage renal disease
| Variable | End stage renal disease | |
|---|---|---|
| No (n = 17) | Yes (n = 15) | |
| *p = 0.033, pc = 0.066; OR = 10.6 (95% CI, 1.1 to 103), power 65.9%. | ||
| **p = 0.028, pc = 0.168; OR = 0.13 (95% CI, 0.02 to 0.80), power 70.5%. | ||
| †p = 0.046, pc = 0.184; OR = 2.25 (95% CI, 1.47 to 3.43), power 15.9%. | ||
| ‡p<0.01, pc<0.02; OR = 0.4 (95% CI, 0.24 to 0.64), power 22.7%. | ||
| CI, confidence interval; IFNγ, interferon γ; IL10, interleukin 10; OR, odds ratio; TNFα, tumour necrosis factor α. | ||
| Age at diagnosis (years) (median (range)) | 54 (19 to 70) | 55 (25 to 62) |
| Disease duration (years) (median (range)) | 5 (1 to 10) | 6 (1 to 20) |
| IFNγ +874 T/T (high) | 7 (41%) | 4 (27%) |
| IFNγ +874 A/A (low) | 1 (6%) | 6 (40%)* |
| TNFα −238 G/A (high) | 1 (6%) | 5 (33%) |
| IL10 −1082, −819, −592 | ||
| GCC/GCC (high) | 1 (6%) | 5 (33%) |
| GCC/ACC (intermediate) | 9 (53%) | 2 (13%)** |
| CTLA4 −318 C/C | 12 (71%) | 15 (100%)† |
| CTLA4 (AT)n repeats with n = 25 or more | 7 (41%)‡ | – |