Table 1

 Stratification of patients with Wegener’s granulomatosis defined by end stage renal disease

VariableEnd stage renal disease
No (n = 17)Yes (n = 15)
*p = 0.033, pc = 0.066; OR = 10.6 (95% CI, 1.1 to 103), power 65.9%.
**p = 0.028, pc = 0.168; OR = 0.13 (95% CI, 0.02 to 0.80), power 70.5%.
†p = 0.046, pc = 0.184; OR = 2.25 (95% CI, 1.47 to 3.43), power 15.9%.
‡p<0.01, pc<0.02; OR = 0.4 (95% CI, 0.24 to 0.64), power 22.7%.
CI, confidence interval; IFNγ, interferon γ; IL10, interleukin 10; OR, odds ratio; TNFα, tumour necrosis factor α.
Age at diagnosis (years) (median (range))54 (19 to 70)55 (25 to 62)
Disease duration (years) (median (range))5 (1 to 10)6 (1 to 20)
IFNγ +874 T/T (high)7 (41%)4 (27%)
IFNγ +874 A/A (low)1 (6%)6 (40%)*
TNFα −238 G/A (high)1 (6%)5 (33%)
IL10 −1082, −819, −592
GCC/GCC (high)1 (6%)5 (33%)
GCC/ACC (intermediate)9 (53%)2 (13%)**
CTLA4 −318 C/C12 (71%)15 (100%)†
CTLA4 (AT)n repeats with n = 25 or more7 (41%)‡