Distribution of SNPs at amino acid positions 16 and 27 in patients with rheumatoid arthritis (RA) and in healthy controls (HC)
| Amino acid position | RA (n = 154) No (%) | HC (n = 198) No (%) | p | pc | OR | 95% CI |
|---|---|---|---|---|---|---|
| Genotype | ||||||
| ArgArg16 | 20 (13) | 16 (8) | NS | |||
| ArgGly16 | 80 (52) | 69 (35) | 0.0016 | 0.0048 | 2.02 | 1.31 to 3.11 |
| GlyGly16 | 54 (35) | 113 (57) | <0.0001 | <0.0001 | 0.41 | 0.26 to 0.63 |
| GlnGln27 | 46 (30) | 68 (34) | NS | |||
| GlnGlu27 | 85 (55) | 77 (39) | 0.0026 | 0.0078 | 1.93 | 1.26 to 2.97 |
| GluGlu27 | 23 (15) | 53 (27) | 0.0088 | 0.0264 | 0.48 | 0.28 to 0.83 |
| Allele | ||||||
| Arg | 120 (39) | 101 (26) | 0.0002 | 0.0004 | 1.86 | 1.35 to 2.57 |
| Gly | 188 (61) | 295 (74) | 0.0002 | 0.0004 | 0.54 | 0.39 to 0.74 |
| Carrier | ||||||
| Arg | 100 (65) | 85 (43) | <0.0001 | <0.0001 | 2.46 | 1.59 to 3.80 |
| Non-Arg | 54 (35) | 113 (57) | <0.0001 | <0.0001 | 0.41 | 0.26 to 0.63 |
| Gln | 131 (85) | 145 (73) | 0.0088 | 0.0176 | 2.08 | 1.21 to 3.59 |
| Non-Gln | 23 (15) | 53 (27) | 0.0088 | 0.0176 | 0.48 | 0.28 to 0.83 |