Table 4

 Concordance between probands and siblings for the combination of two affected joint sites with symptomatic osteoarthritis in patients with familial osteoarthritis at multiple sites

Osteoarthritis sitesSibling OA+Sibling OA−Crude OR (95%CI)Adjusted OR (95%CI)
Results are expressed as crude and adjusted odds ratios with 95% confidence intervals for age, sex, and body mass index in the191 sibling pairs included in the GARP study.
CI, confidence interval; GARP, genetics, arthrosis and progression; OA+, with osteoarthritis; OA−, without osteoarthritis; OR, odds ratio.
Hand–spineProband OA+65471.3 (0.8 to 2.4)1.5 (0.8 to 2.7)
Proband OA−4039
Hand–hipProband OA+7213.1 (1.1 to 8.3)3.4 (1.1 to 10.4)
Proband OA−16147
Hand–kneeProband OA+6420.6 (0.2 to 1.5)0.6 (0.2 to 1.7)
Proband OA−28115
Knee–hipProband OA+2142.1 (0.4 to 10.6)1.7 (0.3 to 9.2)
Proband OA−11164
Knee–spineProband OA+12390.7 (0.4 to 1.6)0.7 (0.3 to 1.6)
Proband OA−4199
Hip–spineProband OA+18215.3 (2.5 to 11.7)4.7 (2.1 to 10.4)
Proband OA−21131