Evidence of cost effectiveness for the proposed interventions
Intervention | Comparator | Perspective | Duration | Discounting | Effectiveness | C1-C2 | E1-E2 | ICER |
---|---|---|---|---|---|---|---|---|
C1, total costs with intervention; C2, total costs with comparator; E1, effect with intervention; E2, effects with comparator; ICER, incremental cost effectiveness ratio, base case scenario; PUB, perforation, ulcer, or bleed; QALYs, quality adjusted life years. | ||||||||
Paracetamol | Ibuprofen | Institutional/payer | 6 months | No | PUB averted | $63000–112000 | 995–980 | −3182 |
Rofecoxib | Institutional/payer | 6 months | No | PUB averted | $63000–471000 | 995–991 | −99512 | |
Celecoxib | Institutional/payer | 6 months | No | PUB averted | $63000–474000 | 995–990 | −89347 | |
Ibuprofen+GI protector | Institutional/payer | 6 months | No | PUB averted | $63000–556000 | 995–988 | −68472 | |
Rofecoxib | Ibuprofen | Institutional/payer | 6 months | No | PUB averted | $471000–112000 | 991–980 | 31770 |
NSAIDs | Institutional/payer | 1 year | 3% | PUB averted | – | – | 4738 | |
Celecoxib | Ibuprofen | Institutional/payer | 6 months | No | PUB averted | $474000–112000 | 990–980 | 33518 |
Ibuprofen+GI protector | Ibuprofen | Institutional/payer | 6 months | No | PUB averted | $556000–112000 | 988–980 | 54146 |
NSAIDs+misoprostol (all patients with OA) | NSAIDs | Canadian Health services | 3 months | No | PUB averted | $32396–25622 | 96–86 | 684 |
NSAIDs+misoprostol (patients with OA aged ⩾65 years) | NSAIDs | Canadian Health services | 3 months | No | PUB averted | $28971–25622 | 91–86 | 644 |
Dicerhein+standard treatment | Standard treatment | Societal | 9 months | No | Lequesne function | F2360–2272 | 2.2–1.2 | 88 |
THR (women, 60 years) | Conventional treatment | Societal | Life | 5% | QALYs | $47649–165440 | 4.16–2.16 | −17121 |
THR (men, ⩾85 years) | Conventional treatment | Societal | Life | 5% | QALYs | $30580–21432 | 4.16–2.16 | 4754 |
THR | No THR | Societal | 1 year | No | QALYs | $9990–0 | 0.84–0.29 | 18164 |
THR | No THR | NHS | Life | 6% | QALYs | £4804–0 | 8.39–0 | 573 |
THR | No THR | Irish institutional | 2 years | No | QALYs | £472.06–0 | 74.2–48.8 | 19 |