Table 3

 Number (%) of patient responders using WOMAC 20, 50, and 70 minimum clinically important response levels

Patient responder definitionsTreatment groupDifference
AC+H (n = 127)AC* (n = 127)[(AC+H)−AC)]p Value
*One patient in the AC group did not have a baseline WOMAC questionnaire completed and thus was not included in the analysis.
†Secondary effectiveness measures from main study.
‡Analysis controlled for the type I experiment-wise error rate by distributing α over all response levels using Bonferroni adjustment α/6 = 0.05/6 = 0.0083.
AC, appropriate care; AC+H  =  appropriate care + hylan G-F 20.
Original effectiveness measures
WOMAC 20P†87 (69%)51 (40%)29%0.0001‡
WOMAC 20PFS†79 (62%)45 (35%)27%0.0001‡
Alternative responder criteria
WOMAC 50P53 (42%)20 (16%)26%<0.0001‡
WOMAC 50PFS43 (34%)12 (9%)25%<0.0001‡
WOMAC 70P26 (20%)10 (8%)12%0.0118
WOMAC 70PFS20 (16%)6 (5%)11%0.0100