Demographic variables and disease status at baseline
| Baseline measure | AC+H (n = 127) | AC (n = 128) | |
|---|---|---|---|
| Values are mean (SD) or n (%). | |||
| *Radiology grading is based on central grading, which may have differed from the site investigator’s determination for patient eligibility. | |||
| AC, appropriate care; AC+H, appropriate care + hylan G-F 20; NSAID, non-steroidal anti-inflammatory drug; OA, osteoarthritis. | |||
| Age (years) | 62.6 (9.4) | 63.5 (10.5) | |
| Body mass index (kg/m2) | 32.1 (8.0) | 32.9 (7.2) | |
| Duration (years) of OA symptoms | |||
| Study knee | 9.0 (9.5) | 9.9 (9.7) | |
| Other knee | 7.4 (8.8) | 8.3 (9.3) | |
| Sex: female | 86 (68%) | 93 (73%) | |
| Previous treatment for OA of the knee(s) | |||
| Acetaminophen | 100 (79%) | 109 (85%) | |
| NSAIDs | 120 (94%) | 110 (86%) | |
| Previous surgery, study knee | 40 (31%) | 39 (30%) | |
| Previous surgery, other knee | 40 (31%) | 23 (18%) | |
| Radiology grading within 1 year (central grading*) | |||
| Not reported | 0 (0%) | 1 (1%) | |
| Grade 0 | 4 (3%) | 4 (3%) | |
| Grade I | 17 (13%) | 11 (9%) | |
| Grade II | 32 (25%) | 33 (26%) | |
| Grade III | 49 (39%) | 37 (295) | |
| Grade IV | 25 (205) | 42 (33%) | |
| OA at baseline | |||
| Other knee affected | 109 (86%) | 108 (84%) | |
| Other joints affected | 95 (75%) | 87 (68%) | |