Table 3

 Relation between longitudinal change in tibial cartilage volume in men over two years and sex hormones and metabolic bone markers

VariableUnivariate analysis regression coefficient (95% CI)*p ValueMultivariate analysis† regression coefficient (95% CI)*p Value
*Change in cartilage per unit increase in corresponding variable.
†Multivariate analysis with age, body mass index, baseline tibial cartilage volume, tibial plateau area, and total bone mineral content in regression equation.
CI, confidence interval.
Hormones
Free testosterone1.12 (0.21 to 2.03)0.021.16 (0.09 to 2.23)0.036
Sex hormone binding globulin−0.6 (−11.3 to 10.1)0.91−0.22 (−16.2 to 15.7)0.98
Oestrogen0.8 (−5.9 to 7.5)0.813.6 (−2.64 to 9.78)0.24
Dehydroepianosterone sulphate22.3 (−46.6 to 91.4)0.5129.7 (−79.2 to 138.7)0.57
Luteinising hormone51.9 (−31.8 to 135.6)0.2148.3 (−43.3 to 139.8)0.28
Biochemical bone turnover markers
Pyridinoline (PYD)3.5 (−2.0 to 9.0)0.201.9 (−3.4 to 7.3)0.46
Deoxypyridinoline (DPD)14.0 (−22.5 to 50.5)0.437.5 (−29.6 to 44.7)0.68
N-telopeptide (NTx)19.4 (−2.1 to 40.9)0.0715.1 (1.5 to 28.7)0.057
Osteocalcin−47.1 (−128.0 to 33.9)0.24−55.4 (−149.1 to 38.4)0.23