Histological and immunohistochemical evaluation in spondyloarthropathy at baseline and week 12 in infliximab treated patients of study population I (n = 10)
| Study population I (n = 10 infliximab) | p Value | ||
|---|---|---|---|
| Baseline | Week 12 | ||
| Semiquantitative histological and immunohistochemical scores are given as median (range). The immunohistochemical markers CD83 and CD1a (sublining layer) were scored as present (+) or absent (−). The p value was calculated for study population I using the paired Wilcoxon signed rank test for the semiquantitative scores and the McNemar test for the dichotomous scores. | |||
| NC, not calculable. | |||
| Lining layer | |||
| Synovial lining layer thickness | 1.5 (1 to 2) | 1 (1 to 1.5) | 0.015 |
| αVβ3 lining | 0 (0 to 3) | 1 (0 to 2.5) | 0.516 |
| VCAM-1 lining | 3 (1.5 to 3) | 1.5 (1 to 3) | 0.034 |
| ICAM-1 lining | 3 (1.5 to 3) | 2.5 (1.5 to 3) | 0.238 |
| E-selectin lining | 0 (0 to 1.5) | 0 (0 to 0.5) | 0.180 |
| CD163 lining | 2 (0 to 2.5) | 1.5 (0 to 3) | 0.864 |
| Blood vessels | |||
| Vascularity | 1.75 (1 to 3) | 1.25 (1 to 2.5) | 0.339 |
| von Willebrand factor | 3 (0 to 3) | 1.5 (1 to 3) | 0.170 |
| CD146 | 3 (1 to 3) | 1.5 (0 to 3) | 0.105 |
| αVβ3 endothelial | 1 (0 to 2.5) | 0 (0 to 1.5) | 0.058 |
| VCAM-1 endothelial | 0 (0 to 1.5) | 0 (0 to 1.5) | 0.180 |
| ICAM-1 endothelial | 3 (0 to 3) | 2.5 (1 to 3) | 1.000 |
| E-selectin endothelial | 1.5 (0 to 3) | 1 (0 to 2.5) | 0.230 |
| Sublining layer | |||
| VCAM-1 sublining | 1 (0 to 3) | 0 (0 to 2.5) | 0.173 |
| ICAM-1 sublining | 3 (0 to 3) | 1.25 (0.5 to 3) | 0.141 |
| E-selectin sublining | 2 (0.5 to 3) | 1 (0 to 2) | 0.034 |
| Degree of inflammatory cell infiltration | 1.75 (0.5 to 2.5) | 0.75 (0 to 2) | 0.018 |
| Number of neutrophils | 0.5 (0 to 3) | 0 (0 to 0) | 0.041 |
| Number of lymphoid aggregates | 1.75 (0 to 3) | 0.5 (0 to 3) | 0.073 |
| CD3 | 2 (0 to 3) | 0.5 (0 to 2) | 0.026 |
| CD4 | 1.5 (0 to 3) | 0.5 (0 to 2) | 0.076 |
| CD8 | 2 (0 to 2.5) | 1 (0 to 1) | 0.061 |
| CD19 | 1 (0 to 3) | 0 (0 to 1) | 0.059 |
| CD20 | 1.5 (0 to 3) | 1 (0 to 3) | 0.750 |
| Number of plasma cells | 0.5 (0 to 3) | 0 (0 to 3) | 0.258 |
| CD38 | 1.5 (0 to 3) | 1.5 (0 to 3) | 0.516 |
| CD138 | 1 (0 to 3) | 1 (0 to 3) | 0.680 |
| CD68 | 2 (0 to 3) | 1 (0.5 to 2) | 0.034 |
| CD163 | 1.25 (0 to 3) | 0.5 (0 to 2.5) | 0.469 |
| CD83 (+/−) | 4/9 | 0/9 | NC |
| CD1a (+/−) | 6/9 | 2/9 | 0.125 |