Table 1

 Effect of infliximab treatment on titres of IgM RF and anti-CCP antibodies in RA

Cut off pointPatients (n)BaselineWeek 30p Value
*Manufacturer’s cut off point. Median values (range) are given. Wilcoxon signed rank test.
IgM RF (assay using particles sensitised with rabbit IgG)
⩾4054320 (40–5120)160 (0–5120)<0.001
⩾8048320 (80–5120)160 (0–5120)<0.001
⩾16041320 (160–5120)160 (0–5120)<0.001
Total cohort62160 (0–5120)160 (0–5120)<0.001
IgM RF (assay using particles sensitised with human IgG)
⩾4055160 (40–5120)160 (0–5120)0.038
⩾8046320 (80–5120)160 (0–5120)0.017
⩾16039320 (160–5120)160 (0–5120)0.023
Total cohort62160 (0–5120)160 (0–5120)0.038
Anti-CCP antibodies
>50 U*41880 (65–5236)719 (54–8802)0.530
Total cohort62535 (5–5236)447 (7–8802)0.240