Table 2

Correlation coefficients, significance, and number of observations of the variables analysed

		Larsen score	Larsen score	ESR	CRP	COMP	RF IgG	RF IgA	RF IgM	Anti-CCP	Anti-IL1α	Epitope single dose
		year 5	year 10	year 0	year 0	year 0	year 0	year 0	year 0	year 0	year 0
Correlation significant at the 0.05 level; correlation significant at the 0.01 level; **correlation significant at the 0.001 level (all two tailed).
Anti-CCP, antibodies against cyclic citrullinated peptide; anti-IL1α, antibodies against interleukin 1α; COMP, cartilage oligomeric matrix protein; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; n, number of patients; PC, Pearson correlation; RF, rheumatoid factor.
Larsen score (year 10)	(PC)	0.848***
Larsen score (year 10)	(n)	129

ESR year 0	(PC)	0.436***	0.397***
	(n)	139	155
CRP Year 0	(PC)	0.403***	0.391***	0.737***
	(n)	116	128	147
COMP year 0	(PC)	0.198*	0.133	0.228**	0.221**
	(n)	133	150	169	142

IgG RF year 0	(PC)	0.233**	0.205*	0.124	0.036	−0.105
	(n)	136	152	174	143	166
IgA RF year 0	(PC)	0.392***	0.363***	0.137	0.047	−0.106	0.593***
	(n)	136	152	174	143	166	176
IgM RF year 0	(PC)	0.233**	0.248**	0.129	0.164	−0.133	0.579***	0.610***
	(n)	136	152	174	143	166	176	176

Anti-CCP year 0	(PC)	0.344***	0.420***	0.128	0.131	−0.117	0.296***	0.556***	0.464***
Anti-CCP year 0	(n)	136	152	174	143	166	176	176	176

Anti-IL1α year 0	(PC)	−0.111	−0.092	0.004	−0.016	0.055	0–.103	0.021	−0.086
Anti-IL1α year 0	(n)	141	157	181	148	171	176	176	176

Single dose shared epitope	(PC)	0.108	0.114	0.074	0.095	−0.093	0.018	0.145	0.186*	0.263**	−0.080
Single dose shared epitope	(n)	137	154	169	139	162	165	165	165	165	171

Double dose shared epitope	(PC)	0.145	0.115	0.040	0.171*	0.033	0.066	0.126	0.095	0.191*	−0.103	0.288**
Double dose shared epitope	(n)	138	155	171	141	164	167	167	167	167	173	171