Table 4

 Literature review of 24 well described cases of HELLP syndrome complicating APS

Authors, case, age,age of HELLP onsetHistory and previous diagnosisAntiphospholipid antibodies/ TherapyFetal outcomeMother’s outcome
CT, prednisone; ASP, low dose aspirin.
Kinoshita8
Case 1
25 years, 23 weeksNo diagnosisLA, aCL/No therapyFetal deathLiver infarction
29 years, 29 weeksHELLP, 1 fetal deathNo therapyLive birthPre-eclampsia. Liver infarction. 3rd pregnancy with live birth with CT
Hochfeld9
Case 2
37 years, 21 weeksSuperficial phlebitis, 3 fetal losses, APSLA, aCL/ASPFetal deathFatal catastrophic syndrome
Ornstein10
Case 3
29 years, 31 weeksNo diagnosisaCL/No therapyLive birth
Case 4
33 years, 18 weeksThrombophlebitis, SLE/APSLA, aCL/ASP, heparinLive birthSkin necrosis
Ilbery11
Case 5
33 years, 37 weeksNo diagnosisLA, aCL/No therapyLive birthSkin necrosis. Adrenal and liver infarction
Alsulyman12
Case 6
25 years, 17 weeksThrombophlebitis, APSLA/HeparinFetal death
Case 7
21 years, 17 weeksNo diagnosisLA/No therapyFetal death
Case 8
24 years, 19 weeksNo diagnosisLA, aCL/No therapyFetal deathPre-eclampsia. Liver infarction
Segal13
Case 9
27 years, 34 weeksNo diagnosisaCLLive birthPre-eclampsia. Budd-Chiari syndrome
Amant14
Case 10
30 years, 29 weeksThrombophlebitisLA/ASP, heparinLive birthLiver infarction
Case 11
29 years, 35 weeks1 fetal loss, no diagnosisaCL/ASPLive birthLiver infarction
Nagayama15
Case 12
28 years, 16 weeks1 embryonic loss, no diagnosisaCL/No therapyInduced abortion
Neuwelt16
Case 13
31 years, 7 months2 fetal deaths, pre-eclampsia, no diagnosisLA, aCL/No therapyNeonatal deathPre-eclampsia. Catastrophic syndrome 31 years later
Mc Mahon17
Case 14
26 years, 18 weeksNo diagnosisLA/No therapyFetal death
Fehr18
Case 15
30 years, 15 weeksThrombophlebitis, stroke, SLEaCL/ASPFetal deathLiver infarction
Sinha19
Case 16
26 years, 25 weeksNone, SLEaCL/ASP, heparinNeonatal deathPre-eclampsia. Fatal catastrophic syndrome
Pauzner20
Case 17
33 years, 25 weeks13 spontaneous abortions, popliteal artery and femoral vein thrombosis, APSLA, aCL/ASP, heparinNeonatal deathPre-eclampsia. Liver infarction
Case 18
37 years, 17 weeks1 fetal death, liver infarction, APSLA, aCL/ASP, heparinFetal deathLiver infarction
Case 19
31 years, 17 weeks3 fetal deaths, APSLA, aCL ASP, heparinInduced abortionLiver infarction
Case 20
28 years, 8 weeks3 fetal deaths, thrombophlebitis, APSLA, aCL/HeparinInduced abortionLiver infarction
Haram21
Case 21
28 years, 18 weeksRecurrent thrombophlebitis and fetal losses, APSLA, aCL/ASP, heparinInduced abortion
Roberts22 Case 22
30 years, 36 weeksFetal death, SLE/APSLA ASP, heparinLive birthPre-eclampsia. Renal microangiopathy. Cerebral haemorrhage
Queyrel7
Case 23
25 years, 27 weeks2 fetal deaths, no diagnosisLA, aCL, No therapyLive birth
Case 24
32 years, 24 weeksThrombophlebitis, no diagnosisLA, No therapyInduced abortionSkin necrosis