Table 3

 Characteristics of six women with APS complicated with HELLP who had seven subsequent pregnancies

Patient ID/AgeKnown diseasePrior eventsTherapyOutcome
CT, prednisone; HC, hydroxychloroquine 400 mg/day; LMWH, low molecular weight heparin; ASP, aspirin 100 mg/day; IVFET, in vitro fertilisation with embryo transfer.
Case 1
23 yearsSLE/APSNormal pregnancy before SLE onset, 2 fetal deaths after
25 yearsHELLP at 31 weeksCT 10 mg/day, HC, ASP, LMWH 8 000U/dayLive birth
28 yearsCT 10 mg/day, HC, ASP, LMWH 8000U/dayHELLP at 33 weeks. Live birth
Case 2
35 yearsSLE/APSIVFET HELLP at 18 weeksLMWH 3 000 U/dayFetal death
37 yearsIVFETCT 10 mg/day, HC, LWMH 8000 U/dayEmbryonic loss 15 days after transfer
Case 3
23 yearsSLE/APSHELLP at 23 weeksNoFetal death
25 yearsCT 10 mg/day, HC, ASP, LMWH 4000 U/dayLive birth at 37 weeks
27 yearsCT 10 mg/day, HC, ASP, LMWH 4000 U/dayLive birth at 38 weeks
Case 4
28 yearsNoHELLP at 40 weeks with eclampsia. Thrombophlebitis in post-partum periodNoLive birth. Diagnosis of primary APS
32 yearsAPSLWMH 14 000 U/day, ASPLive birth at 38 weeks
Case 5
32 yearsFalse positive syphilis serologyHELLP at 30 weeksNoLive birth but death at 5 months of life. Diagnosis of primary APS
APSWith eclampsiaLWMH 6 000 U/day, ASPLive birth at 39 weeks
Case 6
29 years1 embryonic lossHELPP at 37 weeksNoLive birth
32 yearsWith eclampsiaAPS, Calcium heparin 0.6 ml×2Live birth at 39 weeks