Table 2

 Patients’ outcome under anti-TNF alpha therapy

No.SexMain clinical expressionASD duration (years)AgeMain symptomsTherapyRemaining symptomsFollow up
TypeAssociated drugResponse
PDN, prednisone; AZA, azathioprine; MethylPDN, methylprednisolone; IV Ig, intravenous polyvalent immunoglobulin; MTX, methotrexate.
1FSystemic233Fever, arthralgia, rashEtanercept 25 mg ×2/weekPDN 80 mg/dayRemissionNone5 months. Anti-TNF stopped (other: drug availability)
2FArticular555Fever, polyarthritis, rashEtanercept 25 mg ×2/weekAZA 100 mg/day PDN 30 mg/dayPartial responseIsolated fever12 months. Anti-TNF stopped (lack of efficacy)
Infliximab 5 mg/kgAZA 100 mg/day MethylPDN 1g PDN 30 mg/dayPartial responseIsolated fever10 months. Anti-TNF stopped (lack of efficacy)
3MArticular755PolyarthritisEtanercept 25 mg ×2/weekIV Ig1FailurePolyarthritis3 months. Anti-TNF stopped (lack of efficacy)
4FArticular536Fever, polyarthritis, fatigueEtanercept 25 mg ×2/weekPDN 20 mg/dayPartial responseOligoarthritis43 months. Anti-TNF ongoing
5FArticular1729PolyarthritisInfliximab 3 mg/kgMTXFailurePolyarthritis1 month. Anti-TNF stopped (side effects)
6FSystemic274Fever, arthralgia, rashInfliximab 5 mg/kgPDN 20 mg/day MTX 15 mg/weekPartial responseRash, arthralgia1 month. Anti-TNF stopped (side effects)
7MArticular1728Fever, polyarthritis, myalgiaInfliximab 3 mg/kgPDN 40 mg/day MTX 7.5 mg/weekFailureFever, arthritis, myalgia Polyarthritis, myalgia2 months. Anti-TNF stopped (side effects)
RashEtanercept 25 mg ×2/weekPDN 40 mg/day MTX 7.5 mg/weekPartial responseRash, arthralgia1 month. Anti-TNF stopped (side effects)
8FArticular661Polyarthritis, rashInfliximab 3 mg/kgPDN 10 mg/day MTX 17.5 mg/weekRemissionNone44 months. Anti-TNF ongoing
9FArticular444PolyarthritisInfliximab 3 mg/kgPDN 50 mg/day MTX 15 mg/weekPartial responseFew arthritis34 months. Anti-TNF ongoing
10FSystemic273Fever, arthralgia, fatigueInfliximab 3 mg/kgPDN MTX 15 mg/weekPartial responseArthralgia, fatigue12 months. Anti-TNF stopped (lack of efficacy)
11FArticular2132Fever, polyarthritis, rashEtanerceptPDN 15 mg/day MTX 7.5 mg/weekPartial responseFew arthritis10 months. Anti-TNF stopped (lack of efficacy)
25 mg ×2/week
Infliximab 3 mg/kgPDN 12 mg/day MTX 7.5 mg/weekPartial responseFew arthritis7 months. Anti-TNF stopped (lack of efficacy)
12MArticular1229Fever, polyarthritis, rashInfliximab 3 mg/kgMTX 15 mg/weekRemissionNone12 months. Anti-TNF stopped(lack of efficacy)
13FArticular218PolyarthritisEtanerceptPDN 10 mg/dayPartial responseFew arthritis35 months. Anti-TNF ongoing
Fatigue25 mg ×2/weekMTX 10 mg/week
14MArticular325Polyarthritis, rashInfliximab 3 mg/kgPDN 10 mg/dayRemissionNone16 months. Anti-TNF ongoing
MTX 15 mg/week
15FArticular1229Fever, arthralgiaInfliximab 3 mg/kgPDN 5 mg/day MTX 12.5 mg/weekRemissionNone36 months. Anti-TNF ongoing
16FSystemic1437Fever, arthralgia, rashInfliximab 3 mg/kgPDN 20 mg/day AZA 150 mg/dayPartial responseArthralgia, rash9 months. Anti-TNF stopped (lack of efficacy)
17MArticular518Fever, polyarthritisEtanercept 25 mg ×2/weekPDN 20 mg/dayPartial responseFew arthritis9 months. Anti-TNF stopped (lack of efficacy)
Infliximab 3 mg/kgPDN 15–20 mg/day MT X 7.5 mg/weekPartial responseFew arthritis3 months. Anti-TNF ongoing (lack of efficacy)
18FArticular1146Fever, polyarthritisEtanercept 25 mg ×2/weekPDN 15– 20 mg/day MTX 20 mg/weekPartial responseFew arthritis6 months. Anti-TNF ongoing
19FSystemic732Fever, polyarthritis, rashEtanercept 25 mg ×2/weekPDN 15– 20 mg/dayFailureFever, arthritis, rash3 months, Anti-TNF stopped (lack of efficacy)
Sore throatInfliximab 3 mg/kgPDN 15– 20 mg/dayPartial responseFew arthritis, rash4 months. Anti-TNF stopped (other: serious burn)
20FArticular1560Fever, polyarthritis, rashInfliximab 3 mg/kgPDN 45 mg/day MTX 17.5 mg/weekPartial responseFew arthritis8 months. Anti-TNF ongoing