Table 4

 Change in American College of Rheumatology (ACR) Core Data Set measures over 12 months in rheumatoid arthritis clinical trial of leflunomide versus methotrexate versus placebo

MeasureLeflunomidePlaceboMethotrexateEffect sizeRelative efficiency
Sources: Tugwell et al. Arthritis Rheum 2000;43:506–1449 and Strand et al. Arch Int Med 1999;159:2542–50.50
(M)HAQ, (modified) Health Assessment Questionnaire, ESR, erythrocyte sedimentation rate.
Tender joints−7.7−3.0−6.6−0.591.00
Swollen joints−5.7−2.9−5.4−0.440.56
Assessor global−2.8−1.0−2.4−0.681.33
ESR−6.3+2.6−6.5−0.410.48
HAQ−0.45+0.03−0.26−0.801.84
MHAQ−0.29+0.07−0.15−0.691.37
Pain−2.2−0.4−1.7−0.651.21
Patient global−2.1+0.1−1.5−0.811.88