Changes from baseline in synovial tissue indices in the 19 patients who underwent arthroscopy
| Cell type | Combined placebo groups | IFNβ, 2.2 μg | IFNβ, 44 μg |
|---|---|---|---|
| Values are median per cent change (range). | |||
| Data represent total cell count in 18 high power fields corrected for the percentage of actual tissue in the analysed area for cellularity, CD68+ macrophages, CD55+ fibroblasts, and CD3+ lymphocytes. There were no significant differences in change between the placebo group and either IFNβ group. | |||
| IFNβ, interferon beta. | |||
| CD68+ macrophages | −12 (−212 to 150), n = 7 | 85 (−59 to 515), n = 5 | −46 (−320 to 111), n = 7 |
| Intimal lining CD68+ macrophages | −22 (−169 to 160), n = 7 | 22 (−43 to 109), n = 5 | −7 (−228 to 23), n = 7 |
| CD55+ fibroblasts | 1 (−347 to 290), n = 7 | 106 (−94 to 293), n = 5 | 1 (−370 to 532), n = 7 |
| CD3+ lymphocytes | −4 (−446 to 517), n = 7 | −2 (−356 to 32), n = 5 | −4 (−253 to 65), n = 7 |