Adverse events
| Anakinra + MTX (n = 250) | Placebo + MTX (n = 251) | |
|---|---|---|
| MTX, methotrexate; ISR, injection site reaction. | ||
| Adverse events (%) | 90 | 81 |
| Adverse events leading to withdrawal (%) | 14 | 13 |
| ISRs (%) | 65 | 24 |
| ISRs leading to withdrawal (%) | 8.4 | 0.8 |
| Serious adverse events (%) | 4 | 3 |
| Serious adverse events leading to withdrawal (%) | 0.8 | 1 |