Infliximab 3 mg/kg | Placebo | |||
---|---|---|---|---|
Before | After | Before | After | |
*Significant reduction from baseline, p<0.05 | ||||
Epidermal counts are given as positive cells/mm. Dermal and synovial counts are given as positive cells/mm2. Results are expressed as mean (SEM). | ||||
CD3+ epidermis | 37 (11) | 26 (11)* | 18 (8) | 43 (20) |
CD3+ dermis | 159 (84) | 136 (54) | 101 (34) | 167 (54) |
CD3+ synovium | 67 (56) | 32 (30)* | 110 (62) | 46 (21) |
CD68+ intimal lining layer | 48 (41) | 5 (3) | 81 (25) | 53 (36) |
CD68+ synovial sublining | 100 (73) | 10 (8)* | 111 (41) | 67 (20) |
TUNEL+ epidermis | 12 (7) | 10 (6) | 33 (13) | 45 (26) |
TUNEL+ synovium | 28 (10) | 22 (10) | 58 (20) | 43 (14) |