Median (25th–75th centiles) values of serum and SF MMP levels
| Controls | OA | RA | |
|---|---|---|---|
| *p<0.001 RA v OA; †p<0.05 RA v OA; ‡p<0.001 RA v controls; §p<0.05 RA v controls; ¶p<0.001 OA v controls; **p<0.05 OA v controls. | |||
| MMP, TIMP, and MMP activity in MMP/α2M levels in serum and synovial fluid of patients with RA and OA and in controls. Values shown are median (25th–75th centiles). | |||
| Synovial fluid | |||
| MMP-1 (U/ml) | 0.0 (0.0–0.01) | 0.28 (0.21–1.23)** | 5.9 (3.6–11.3)*‡ |
| MMP-8 (U/ml) | 0.0 (0.0–0.01) | 0.75 (0.15–2.2)** | 10 (4.7–30.0)*‡ |
| MMP-3 (ng/ml) | 177 (149–249) | 869 (625–7401)** | 22044 (14700–25800)*‡ |
| MMP-2 (U/ml) | 17 (13–19) | 30 (25–35)** | 31 (30–34)‡ |
| MMP-9 (U/ml) | 0.1 (0.07–0.18) | 0.7 (0.4–1.7)** | 4.0 (2.3–6.3)*‡ |
| MMP-13 | Not detectable | Not detectable | Not detectable |
| MMP/α2M (U/ml) | 37 (34–41) | 55 (43–124)** | 470 (334–1321)*‡ |
| TIMP-1 (ng/ml) | 322 (0–1478) | 8961 (5287–16252)¶ | 5717 (1951–9666)‡ |
| Serum | |||
| MMP-1 (U/ml) | 0.06 (0.02–0.1) | 0.06 (0–0.1) | 0.06 (0.06–0.1) |
| MMP-8 (U/ml) | 0.64 (0.6–1) | 1.12 (0.7–2.6)¶ | 4.4 (1.0–6.6)†‡ |
| MMP-3 (ng/ml) | 16 (11–25) | 17 (12–28) | 85 (36–117)*‡ |
| MMP-2 (U/ml) | 5.6 (4.9–6.4) | 6 (4.9–7.0) | 6.15 (5.6–8.0) |
| MMP-9 (U/ml) | 2.1 (1.6–2.6) | 3.0 (2.0–3.6)¶ | 4.6 (3.0–6.4)†‡ |
| MMP-13 | Not detectable | Not detectable | Not detectable |
| MMP/α2M (U/ml) | 86 (77–128) | 88 (80–145) | 172 (71–198)§ |
| TIMP-1 (ng/ml) | 445 (428–627) | 495 (412–1368) | 345 (266–1088)† |