Table 1

RCTs included in the analysis

Ref	Author	NSAID	Dose	Indication	Treated group size	Placebo group size	Outcomes
19	Laerum et al	Diclofenac	150 mg/day	Recurrent renal colic	41	39	GI-minor
25	Wahlström et al	Diclofenac	150 mg/day	Heterotopic ossification after hip arthroplasty	46	50	GI system disorders
37	Laurent et al	Diclofenac	100 mg/day	Proteinuria in glomerular diseases	14	12	GI-minor
43	Bassotti et al	Diclofenac	150 mg/day	Healthy volunteers	8	8	GI-minor
		Indometacin	150 mg/day		8
27	Reis et al	Diclofenac	150 mg/day	Heterotopic ossification after hip arthroplasty	90	90	GI-minor
34	Schnitzer et al	Etodolac	800 mg/day	Knee osteoarthritis	91	90	GI-minor
		Nabumetone	1500 mg/day		89
40	Laine et al	Etodolac	400 mg bid	Gastrointestinal tolerability	18	16	GI-major
		Naproxen	500 mg bid
22	Hoikka et al	Flurbiprofen	200 mg/day	Heterotopic ossification after hip arthroplasty	34	34	GI-minor
30	Elmstedt et al	Ibuprofen	1200 mg/day	Heterotopic ossification after hip arthroplasty	21	22	GI-minor
45	Langman et al	Ibuprofen	2400 mg/day	Osteoarthritis	1564	514	GI system disorders
		Diclofenac	150 mg/day
		Ibuprofen
		Diclofenac
41	Persson et al	Ibuprofen	1200 mg/day	Heterotopic ossification after hip arthroplasty	48	47	GI-minor
48	Doyle et al	Ibuprofen	1200 mg/day	Gastrointestinal tolerability	833	413	GI-minor
26	Schmidt et al	Indometacin	75 mg/day	Heterotopic ossification after hip arthroplasty	102	99	GI system disorders
20	Kjaersgaard et al	Indometacin	75 mg/day	Heterotopic ossification after hip arthroplasty	19	22	Any GI adverse event
42	Scott et al	Indometacin	25 mg/day	Knee osteoarthritis	202	303	GI-minor
47	Eliakim et al	Indometacin	150 mg/day	Acute musculoskeletal disorders	65	513	GI-major
38	Berry et al	Lornoxicam	12 mg/day	Knee and hip osteoarthritis	44	42	GI-minor
21	Lemmel et al	Meloxicam	15 mg/day	Rheumatoid arthritis	162	147	GI system disorders
			7.5 mg/day		159
46	Yocum et al	Meloxicam	3.75-15 mg/day	Osteoarthritis	464	157	Any GI adverse event
		Diclofenac	100 mg/day		153
33	Lipscomb et al	Meloxicam	15 mg/day	Gastrointestinal tolerability	15	15	GI-minor
		Piroxicam	20 mg/day		14
35	Patoia et al	Meloxicam	15 mg/day	Gastrointestinal tolerability	13	13	GI-severe
		Piroxicam	20 mg/day		13
36	Lund et al	Meloxicam	15 mg/day	Knee osteoarthritis	134	137	GI-minor
44	Dougados et al	Meloxicam	15/22.5 mg/day	Ankylosing spondylitis	120	121	GI-major
		Piroxicam	20 mg/day		108
29	Simon et al	Naproxen	500 mg/day	Rheumatoid arthritis	138	101	GI ulcers
18	Gebuhr et al	Naproxen	750 mg/day	Heterotopic ossification after hip arthroplasty	28	27	GI system disorders
49	Schiff et al	Naproxen	1000 mg/day	Knee osteoarthritis	116	116	GI-minor
31	Bono et al	Oxaprozin	1200 mg/day	Tendinitis and bursitis	43	43	GI-major
24	Prupas et al	Tenidap	40-200 mg/day	Rheumatoid arthritis	131	67	GI-minor
23	Gebuhr et al (2)	Tenoxicam	40 mg/day	Heterotopic ossification after hip arthroplasty	35	35	GI system disorders
28	Burssens et al	Tenoxicam	20 mg/day	Heterotopic ossification after hip arthroplasty	26	29	GI-minor
			10 mg/day		29
50	Szpalski et al	Tenoxicam	20 mg/day	Low back pain	37	36	GI-minor
39	Dougados et al (2)	Ximoprofen	30 mg/day	Ankylosing spondylitis	50	95	GI-minor