Table 1

 RCTs included in the analysis

RefAuthorNSAIDDoseIndicationTreated group sizePlacebo group sizeOutcomes
19Laerum et alDiclofenac150 mg/dayRecurrent renal colic4139GI-minor
25Wahlström et alDiclofenac150 mg/dayHeterotopic ossification after hip arthroplasty4650GI system disorders
37Laurent et alDiclofenac100 mg/dayProteinuria in glomerular diseases1412GI-minor
43Bassotti et alDiclofenac150 mg/dayHealthy volunteers88GI-minor
Indometacin150 mg/day8
27Reis et alDiclofenac150 mg/dayHeterotopic ossification after hip arthroplasty9090GI-minor
34Schnitzer et alEtodolac800 mg/dayKnee osteoarthritis9190GI-minor
Nabumetone1500 mg/day89
40Laine et alEtodolac400 mg bidGastrointestinal tolerability1816GI-major
Naproxen500 mg bid
22Hoikka et alFlurbiprofen200 mg/dayHeterotopic ossification after hip arthroplasty3434GI-minor
30Elmstedt et alIbuprofen1200 mg/dayHeterotopic ossification after hip arthroplasty2122GI-minor
45Langman et alIbuprofen2400 mg/dayOsteoarthritis1564514GI system disorders
Diclofenac150 mg/day
Ibuprofen
Diclofenac
41Persson et alIbuprofen1200 mg/dayHeterotopic ossification after hip arthroplasty4847GI-minor
48Doyle et alIbuprofen1200 mg/dayGastrointestinal tolerability833413GI-minor
26Schmidt et alIndometacin75 mg/dayHeterotopic ossification after hip arthroplasty10299GI system disorders
20Kjaersgaard et alIndometacin75 mg/dayHeterotopic ossification after hip arthroplasty1922Any GI adverse event
42Scott et alIndometacin25 mg/dayKnee osteoarthritis202303GI-minor
47Eliakim et alIndometacin150 mg/dayAcute musculoskeletal disorders65513GI-major
38Berry et alLornoxicam12 mg/dayKnee and hip osteoarthritis4442GI-minor
21Lemmel et alMeloxicam15 mg/dayRheumatoid arthritis162147GI system disorders
7.5 mg/day159
46Yocum et alMeloxicam3.75-15 mg/dayOsteoarthritis464157Any GI adverse event
Diclofenac100 mg/day153
33Lipscomb et alMeloxicam15 mg/dayGastrointestinal tolerability1515GI-minor
Piroxicam20 mg/day14
35Patoia et alMeloxicam15 mg/dayGastrointestinal tolerability1313GI-severe
Piroxicam20 mg/day13
36Lund et alMeloxicam15 mg/dayKnee osteoarthritis134137GI-minor
44Dougados et alMeloxicam15/22.5 mg/dayAnkylosing spondylitis120121GI-major
Piroxicam20 mg/day108
29Simon et alNaproxen500 mg/dayRheumatoid arthritis138101GI ulcers
18Gebuhr et alNaproxen750 mg/dayHeterotopic ossification after hip arthroplasty2827GI system disorders
49Schiff et alNaproxen1000 mg/dayKnee osteoarthritis116116GI-minor
31Bono et alOxaprozin1200 mg/dayTendinitis and bursitis4343GI-major
24Prupas et alTenidap40-200 mg/dayRheumatoid arthritis13167GI-minor
23Gebuhr et al (2)Tenoxicam40 mg/dayHeterotopic ossification after hip arthroplasty3535GI system disorders
28Burssens et alTenoxicam20 mg/dayHeterotopic ossification after hip arthroplasty2629GI-minor
10 mg/day29
50Szpalski et alTenoxicam20 mg/dayLow back pain3736GI-minor
39Dougados et al (2)Ximoprofen30 mg/dayAnkylosing spondylitis5095GI-minor