Demographic data, drug treatment, medical history, anti-dsDNA antibodies, SLAM scores, C3/C4 levels, and CR1 levels of all six patients with SLE
Patient | Sex/age/onset of disease | Current drug for treatment of SLE | Clinical manifestation* | Anti-dsDNA† (Farr titre, U/ml) ANA titre ENA profile | SLAM Day 0/day 28 | C3/C4 (g/l) t = 0 h t = 4 h t = 24 h t = 48 h | CR1 on RBC |
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*Clinical manifestation may be acute or in the medical history; †baseline levels of anti-dsDNA antibodies before entering the study; ‡levels at screening visit (2 weeks before) were 0.82/0.19. | |||||||
ENA, extractable nuclear antigen. | |||||||
1 | Female/55/1995 | 7.5 mg Prednisone | Arthritis | 306 | 6/8 | 0.98/0.24‡ | 372 |
400 mg Hydroxychloroquine | Livedo reticularis | 1/ 1280 | 0.63/<0.06 | ||||
Pleuritis | Negative | 0.67/0.11 | |||||
0.82/0.11 | |||||||
2 | Male/26/1984 | 5 mg Prednisone | Skin | 45 | 2/1 | 0.57/0.11 | 106 |
250 mg Chloroquine | Arthritis | 1/80 | 0.49/0.08 | ||||
1000 mg Mycophenolatmofetil | Pleuritis | Negative | 0.53/0.10 | ||||
Renal | 0.55/0.10 | ||||||
Liver/ascites | |||||||
Leucopenia | |||||||
3 | Female/28/1993 | 125 mg Chloroquine | Raynaud’s syndrome | 42 | 9/7 | 1.08/0.16 | 253 |
Renal | 1/320 | 0.95/0.17 | |||||
Skin vasculitis | U1RNP | 0.1/0.15 | |||||
Leucopenia | 1.04/0.17 | ||||||
4 | Female/43/1980 | 5 mg Prednisone | Arthralgia | 62 | 12/9 | 0.85/0.12 | 106 |
50 mg Azathioprine | Myalgia | 1/ 640 | 0.76/0.11 | ||||
Renal | SS-A, SS-B | 0.78/0.11 | |||||
Raynaud’s syndrome | 0.82/0.11 | ||||||
5 | Male/30/2000 | 2.5 mg Prednisone | Renal | 484 | 7/9 | 0.82/0.11 | 27 |
400 mg Hydroxychloroquine | Pleuritis Arthritis | 1/640 Negative | 0.62/0.06 0.78/0.09 | ||||
Cyclophosphamide IV every 3 months | Endocarditis Leuco-lymphopenia | 0.77/0.10 | |||||
2000 mg Mesalazine | Fever | ||||||
Colitis | |||||||
6 | Female/38/1999 | 10 mg Prednisone | Raynaud’s syndrome | 27 | 9/6 | 0.83/0.14 | 54 |
250 mg Chloroquine | Alopecia | 1/640 | 0.77/0.13 | ||||
Livedo reticularis | Negative | 0.77/0.13 | |||||
Arthralgia | 0.82/0.15 | ||||||
Photosensitive rash | |||||||
Neuroradiculitis |