Table 6

 Improvement with leflunomide, methotrexate or placebo for three pooled indices, American College of Rheumatology (ACR) 20 and the Disease Activity Score (DAS)

Pooled index20% Improvement responsez scores*
LeflunomideMethotrexatePlaceboLeflunomide v placeboMethotrexate v placebo
*All z scores p<0.001.
Source: Pincus et al. Arthritis Rheum 2003;48:625–30.48
ACR 2052%46%26%4.363.32
Patient only64%56%33%4.853.00
Assessor only74%69%43%5.124.86
All Core Data Set57%49%29%5.895.12