Table 2

Semiquantitative scores (from 0 as lowest value to 3 as highest value) of the histology and immunohistochemical stainings assessing cellular markers, blood vessels, and adhesion molecules in 11 rheumatoid nodules

Patient NoNodule codeInfliximab treatmentAge of the nodule (years)Central necrosisPalisade layerBlood vesselsPerivascular infiltrationCD3CD4CD8CD20CD68CD16CD146VWFαVβ3E-selectinVCAM-1ICAM-1
Nodules 1–6 were obtained before infliximab treatment, whereas the other nodules were obtained after 2–30 months of infliximab treatment.
NA, not available.
11No3++11110011110002
22No2++11110011220003
33No1++11110022111002
44Baseline4++11NANANANANANANANANANANANA
55Baseline2++22110012110002
66Baseline5++11NANANANANANANANANANANANA
472 Months4++12NANANANANANANANANANANANA
584 Months2++22100011110103
6912 Months5++11000011110002
71012 Months0.25++33210022221003
81130 Months7++22220021121103