Table 1

CNS involvement in SS: reported prevalence

AuthorsPatients with SS (n)Country% With neurological manifestationsNature of CNS disease
*Included patients with possible SS
MS, multiple sclerosis; TIA, transient ischaemic attack.
Lafitte et al, 2001525France17Spinal cord dysfunction
Transverse myelitis
Motor neurone syndrome
Seizures+ tetrapyramidal syndrome+ cerebellar syndrome
Anaya et al, 2000695Colombia3.2MS-like illness
Optic neuritis+epilepsy
Complicated migraine
Coates et al, 1999930Australia0
Tajima et al, 19971021Japan14
Escudero et al, 19951148Spain23Focal neurological deficits
Mauch et al, 19941220Germany10Hemiparesis
Aseptic meningitis
Moll et al, 19931345Holland9Transverse myelitis
Stroke
Bell’s palsy
Pyramidal signs
Hietaharju et al, 19931648Finland23Seizures
Optic neuropathy
Movement disorders
Aseptic meningitis
Hietaharju et al, 1990*1443Finland12.5Aseptic meningitis
Epilepsy
Hyperreflexia
Andonopoulos et al, 1990263Greece1.6Cerebrovascular accident
Binder et al, 19881850UK6Epilepsy
Vertigo
Recurrent TIAs
Alexander et al, 198619USA20MS-like syndrome
Malinow et al, 19852040USA60CNS abnormalities
Molina et al, 19852150USA45Focal defects
Seizures
Aseptic meningitis
Encephalopathy
Myelopathy
Neurogenic bladder