Dose-response data for therapeutic administration of drugs, expressed as a percentage change compared with baseline
| Day | NI | FCA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Vehicle | l-NIL (mg/kg) | SC-236 (mg/kg) | l-NIL+SC-236 (mg/kg) | ||||||
| 21.5 | 43 | 86 | 2.8 | 5.6 | 11.2 | 43+5.6 | |||
| The dose-response curves were significant (p<0.001) for all measurements (see text). | |||||||||
| 1 | 2.1 (0.7) | 95.7 (7.8) | 101.1 (4.5) | 92.8 (7.8) | 96.7 (4.8) | 108.5 (9.7) | 93.7 (7.9) | 102.6 (6.7) | 98.4 (5.8) |
| 5 | 2.1 (0.4) | 73.0 (0.9) | 77.3 (3.4) | 73.8 (1.8) | 73.6 (1.4) | 74.4 (1.8) | 68.7 (4.4) | 62.1 (2.2) | 76.7 (2.2) |
| 14 | 5.2 (0.9) | 81.3 (2.1) | 62.9 (1.6) | 87.1 (7.1) | 86.7 (1.2) | 63.9 (2.0) | 65.5 (3.4) | 39.7 (1.9) | 84.9 (2.0) |
| Urinary NOx | |||||||||
| 1 | −11.2 (0.7) | 487.6 (14) | 480.5 (10.0) | 492.6 (6.8) | 481.5 (9.4) | 477.2 (13.0) | 490.3 (12) | 486.5 (8.4) | 491.5 (5.2) |
| 5 | 7.5 (0.5) | 209.3 (0.5) | 227.7 (1.7) | 173.8 (0.5) | 172.2 (2.3) | 228.9 (1.7) | 200.4 (6.3) | 200.3 (1.7) | 175.7 (2.3) |
| 14 | 8.1 (1.3) | 203.6 (2.0) | 163.3 (2.1) | 126.9 (7.1) | 31.5 (1.6) | 196.0 (3.4) | 195.7 (5.7) | 141.8 (1.8) | 134.2 (3.3) |
| Urinary PGE2 | |||||||||
| 1 | 3.1 (0.7) | 144.3 (4.5) | 140.7 (7.1) | 145.6 (9.4) | 148.1 (6.8) | 149.3 (5.2) | 141.6 (9.5) | 139.6 (6.2) | 142.3 (7.1) |
| 5 | −2.5 (0.5) | 45.4 (6.3) | 40.8 (1.7) | 53.2 (0.5) | 40.7 (1.5) | 45.1 (2.1) | 41.4 (6.3) | 40.4 (1.7) | 48.1 (2.7) |
| 14 | 2.2 (0.4) | 49.3 (3.2) | 53.3 (1.8) | 43.7 (7.1) | 31.5 (1.4) | 38.8 (3.4) | 21.4 (0.4) | 14.5 (1.8) | 34.2 (8.1) |