Toxicity data relating to blood pressure, weight, body mass index, and bone mineral density over two years
| Variable | Active | Placebo | Mann–Whitney U test | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | Wilcoxon (0–1/0–2) | 0 | 1 | 2 | Wilcoxon (0–1/0–2) | ||
| BMI, body mass index; BP, blood pressure. | |||||||||
| Systolic BP (mm Hg) | 140 | 140 | 140 | 0.424/0.551 | 135 | 140 | 130 | 0.038/0.703 | 0.503, year 0 |
| 0.471, year 1 | |||||||||
| 0.620, year 2 | |||||||||
| Diastolic BP (mm Hg) | 80 | 82 | 80 | 0.057/0.818 | 80 | 80 | 80 | 0.070/0.288 | 0.106, year 0 |
| 0.055, year 1 | |||||||||
| 0.424, year 2 | |||||||||
| Weight (kg) | 68 | 71 | 72 | 0.000/0.000 | 69 | 70 | 72 | 0.162/0.031 | 0.551, year 0 |
| 0.218, year 1 | |||||||||
| 0.255, year 2 | |||||||||
| BMI (kg/m2) | 24.9 | 25.7 | 26.2 | 0.000/0.000 | 25.1 | 25.7 | 26.0 | 0.119/0.035 | 0.950, year 0 |
| 0.396, year 1 | |||||||||
| 0.355, year 2 | |||||||||
| Median weight gain | 4 kg | 3 kg | |||||||
| Bone mineral density | 0.308, year 0 | ||||||||
| Femoral neck | 0.8995 | – | 0.8810 | 0.9270 | – | 0.9110 | 0.228, year 2 | ||
| Lumbar spine | 0.193, year 0 | ||||||||
| L2–L4 | 1.0790 | – | 1.0730 | 1.1565 | – | 1.280 | 0.097, year 2 | ||