AS | AS1 | AS2 | Controls | |
---|---|---|---|---|
Values are mean (SEM). | ||||
*p<0.05, **p<0.01, ***p<0.001. | ||||
†Change in cortisol between baseline and 60 minutes. | ||||
ACTH, adrenocorticotrophic hormone; AS, ankylosing spondylitis; AS1, subgroup with normal insulin resistance; AS2, subgroup with increased insulin resistance; DHEAS, dehydroepiandrosterone sulphate; HOMA-IR, homeostasis model insulin resistance index; IL-6, interleukin 6; TNFα, tumour necrosis factor α; 17-OHP, 17α-hydroxyprogesterone. | ||||
Glucose (mmol/l) | 5.27 (0.18) | 4.97 (0.09) | 5.83 (0.428)* | 5.02 (0.11) |
Insulin (μIU/ml) | 14.03 (3.59) | 4.79 (0.52) | 30.9 (5.22)*** | 7.54 (1.66) |
HOMA-IR | 3.52 (0.97) | 1.07 (0.12) | 8.01 (1.51)*** | 1.72 (1.32)* |
Cortisol (nmol/l) | 382 (47) | 371 (63) | 403 (73) | 511 (37) |
Δ Cortisol 60–0† | – | 346.5 (60.7) | – | 207 (79.8) |
ACTH (pg/ml) | 13.9 (1.9) | 14.3 (8.6) | 13.1 (2.3) | 14.1 (1.8) |
17-OHP (ng/ml) | 1.04 (0.21) | 0.85 (0.12) | 1.37 (0.57) | 1.23 (0.22) |
DHEAS (μmol/l) | 5.05 (0.70) | 5.07 (0.60) | 5.01 (1.80) | 5.06 (0.60) |
IL-6 (pg/ml) | 16.6 (2.8)*** | 19.1 (2.2)*** | 12.1 (3.5)*** | 1.41 (0.66) |
TNFα (pg/ml) | 8.5 (1.74)** | 10.2 (2.6)** | 5.42 (0.51) | 4.08 (0.42) |