Table 1

Qualitative grading system used to assess the degree of synovitis in the mouse knee joint, modified from Podworny et al25

I Synovial lining cell hyperplasia II Fibrosis
0, Absent0, Absent
If present If present
1, <50% of the synovial lining shows change1, Mild
2, >50% of the synovial lining shows change2, Diffuse
III Inflammation IV Necrosis
0 Absent0, Absent
If present If present
1, Histiocytes1, Focal
2, Intermediary2, Multifocal
3, Marked3, Diffuse