Table 2

Fas promoter polymorphism frequencies by Ro/La autoantibody status in patients with pSS v controls

PolymorphismpSS Ro/La Status (No (%))All pSSControls
NegativeRo onlyRo+La (ppt−)*Ro+La (ppt+)*
(n = 23)(n = 9)(n = 19)(n = 50)(n = 101)(n = 108)
*Precipitin negative (ppt−) or precipitin positive (ppt+) La autoantibody determined from autoantibody reactivity by counterimmunoelectrophoresis; †all genotype distributions were in Hardy-Weinberg equilibrium; ‡the (−1377, −670) haplotypes were in linkage disequilibrium (p<0.00001) and the (−1377A, −670A) haplotype was not seen in this study; §the Fas−670A allele frequency was significantly greater in patients with Ro/La negative pSS than in patients with Ro/La positive pSS (p = 0.04).
Genotype distributions
Fas (−1377, −670)‡G–A, G–A11 (48)1 (11)5 (26)13 (26)30 (30)33 (31)
G–A, A–G4 (17)1 (11)1 (5)5 (10)11 (11)13 (12)
G–G, G–A6 (26)6 (67)10 (53)21 (42)43 (43)41 (38)
A–G, A–G0 (0)0 (0)1 (5)3 (6)4 (4)1 (1)
G–G, A–G0 (0)0 (0)0 (0)3 (6)3 (3)6 (6)
G–G, G–G2 (9)1 (11)2 (11)5 (10)10 (10)14 (13)
Fas −1377GG19 (83)8 (89)17 (89)39 (78)83 (82)88 (82)
GA4 (17)1 (11)1 (5)8 (16)14 (14)19 (18)
AA0 (0)0 (0)1 (5)3 (6)4 (4)1 (1)
Fas −670GG2 (9)1 (11)3 (16)11 (22)17 (17)21 (19)
GA10 (43)7 (78)11 (58)26 (52)54 (53)54 (50)
AA11 (48)1 (11)5 (26)13 (26)30 (30)33 (31)
Allele frequencies
Fas (−1377,−670)‡G–A0.6960.5000.5530.5200.5640.556
G–G0.2170.4440.3680.3400.3270.347
A–G0.0870.0560.0790.1400.1090.097
Fas −1377G0.9130.9440.9210.8600.8910.903
A0.0870.0560.0790.1400.1090.097
Fas −670A0.696§0.5000.5530.5200.5640.556
G0.3040.5000.4470.4800.4360.444