Association analysis
| Overall study population | Subjects ⩽65 years† | Subjects >65 years | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ROA+ (n = 1355) | ROA− (n = 191) | OR (95%CI) | ROA+ (n = 817) | ROA− (n = 154) | OR (95%CI) | ROA+ (n = 538) | ROA− (n = 37) | OR (95%CI) | |
| †p for trend <0.05. | |||||||||
| OR, odds ratio adjusted for age, sex, body mass index, and bone mineral density. | |||||||||
| Homozygous for 192 bp (%) | 594 (43.8) | 93 (48.7) | Reference | 344 (42.1) | 79 (50.3) | Reference | 250 (46.5) | 14 (37.8) | Reference |
| Heterozygous for 192 bp (%) | 593 (43.8) | 78 (40.8) | 1.2 (0.9 to 1.5) | 368 (45.0) | 60 (38.2) | 1.4 (1.0 to 1.8) | 225 (41.8) | 18 (48.6) | 0.8 (0.5 to 1.3) |
| Non-carriers of 192 bp (%) | 168 (12.4) | 20 (10.5) | 1.4 (0.9 to 2.4) | 105 (12.9) | 15 (9.6) | 1.9 (1.1 to 3.3) | 63 (11.7) | 5 (13.5) | 0.6 (0.2 to 1.7) |