Disease activity and toxicity at week 48
| NA− | FA | NA+ | p Value | Contrasts | ||
|---|---|---|---|---|---|---|
| NA− v FA | NA+ v FA | |||||
| Values are counts (column percentage), mean (SD), or median (interquartile range). | ||||||
| *Good or moderate response. | ||||||
| DAS, disease activity score; FA, patients with full guideline adherence; NA−, patients with a net lower methotrexate dose than the guidelines proposed; NA+, patients with a net higher methotrexate dose than the guidelines proposed. | ||||||
| n | 97 | 180 | 98 | |||
| DAS | 3.2 (1.2) | 3.2 (1.4) | 3.1 (1.1) | 0.61 | – | – |
| Decrease in DAS | −1.4 (1.2) | −1.8 (1.3) | −1.8 (1.2) | 0.05 | 0.020 | 0.80 |
| DAS response | ||||||
| None | 5 (5%) | 16 (8%) | 4 (4%) | |||
| Moderate | 57 (56%) | 70 (33%) | 43 (42%) | 0.02 | 0.011 | 0.30 |
| Good | 35 (34%) | 92 (44%) | 50 (49%) | |||
| Time to response* (weeks) | 27 (12) | 24 (11) | 21 (12) | 0.0062 | 0.14 | 0.031 |
| Observations in response* (n) | 2 (1 to 4) | 4 (2 to 5) | 4 (2 to 6) | 0.0003 | 0.0003 | 0.57 |
| Toxicity index, Fries | 10.9 (4.3 to 20.4) | 8.8 (2.4 to 19.2) | 11.4 (5.3 to 19.6) | 0.30 | – | – |
| Toxicity index, Felson | 15.4 (13.4 to 20.7) | 10.9 (4.2 to 22.2) | 12.9 (7.2 to 22.3) | 0.47 | – | – |