Table 1

Characteristics of 966 respondents* (471 men, 495 women) according to COLIA1 genotype, stratified by sex

CharacteristicsMenp ValueWomenp Value
GGGTTTGGGTTT
Values are means (SD), unless otherwise indicated.
*Within the subsample consisting of subjects living in the western part of the Netherlands, differences in characteristics showed a similar pattern, except that women with the GT genotype reported a higher age at menopause (p = 0.03); †differences in frequencies were examined with χ2 test; ‡median [interquartile range]; §differences in skewed parameters were examined with the Kruskal-Wallis test; ¶differences in means were examined after ln transformation; **values were adjusted for age and body weight.
NA, not applicable
No (%)313 (66.5)139 (29.5)19 (4.0)347 (70.1)131 (26.5)17 (3.4)
Age (years)75.8 (6.4)75.3 (6.8)73.6 (6.0)0.3375.7 (6.6)75.8 (6.7)75.1 (5.4)0.90
Height (cm)172 (15.9)172 (17.0)172 (5.7)0.86158 (16.9)159 (6.3)163 (6.9)0.28
Body weight (kg)77.5 (11.6)78.4 (12.6)76.8 (10.5)0.6871.5 (13.0)69.6 (10.7)71.2 (14.3)0.36
Current smoker (%)27.225.231.60.81†12.416.011.80.57†
Alcohol use (drinks/week)‡6 [1–21]‡7 [2–21]‡12 [3–21]‡0.06§1 [0–6]‡1 [0–6]‡1 [0–3]‡0.68§
Physical activity (total score 1–5)‡3 [3–4]‡3 [2–4]‡3 [2–4]‡0.76§3 [2–4]‡3 [2–4]‡3 [2–4]‡0.83
Heavy lifetime exercise (%)37.837.042.10.91†36.941.129.40.55†
Physical performance7.0 (2.8)6.9 (2.7)7.3 (2.3)0.806.6 (2.8)6.7 (2.9)7.4 (2.9)0.48
Age at menopause (years)NANANANA48.7 (5.5)49.3 (5.0)47.6 (4.7)0.31
QUS measurements
    BUA (dB/MHz)80.2 (1.0)81.0 (1.5)77.6 (4.2)0.7461.6 (0.9)59.4 (1.4)61.7 (3.9)0.74
    SOS (m/s)1626 (2.5)1629 (3.7)1614 (10.0)0.371597 (2.1)1597 (3.4)1601 (9.5)0.87
Biochemical bone markers
    DPD/Cr urine (nmol/mmol)5.09 (0.17)¶**4.92 (0.26)¶**5.18 (0.67)¶**0.566.22 (0.13)¶**5.94 (0.22)¶**6.42 (0.61)¶**0.38
    Osteocalcin (nmol/l)1.96 (0.06)¶**2.21 (0.09)¶**2.01 (0.25)¶**0.022.33 (0.06)¶**2.24 (0.09)¶**2.69 (0.27)¶**0.52