Mean serum hsCRP values in 770 consecutive patients with hip or knee joint replacement due to advanced OA according to selected OA characteristics
| Characteristics | No (%) | hsCRP (mg/l), geometric mean | (95% CI*) | p Value† |
|---|---|---|---|---|
| *Confidence interval; †from linear regression models with log transformed hsCRP as dependent variable; for (log) linear trend over units (VAS, WOMAC pain) or categories (individual WOMAC pain items coded from 0 (none) to 4 (extreme)) if more than two categories; ‡radiographic OA (Kellgren and Lawrence score ⩾2) of replaced joint and contralateral joint; §radiographic OA on ⩾2 finger joints and ⩾1 carpometacarpal joint in addition to uni- or bilateral OA of hip or knee joint; ¶replaced (that is, more affected) joint; **VAS from 0 (no pain) to 100 (extreme pain); ††out of 23 joint regions from neck to foot specifically assessed during the interview (for details see “Methods”); ‡‡Western Ontario McMasters Universities osteoarthritis index available for 619 patients (assessment only included after start of recruitment). | ||||
| Operated joint | 0.7 | |||
| Hip | 402 (52.2) | 2.5 | (2.3 to 2.8) | |
| Knee | 368 (47.8) | 2.5 | (2.2 to 2.7) | |
| OA extent (radiographic) | ||||
| Symmetry‡ | 0.3 | |||
| Unilateral OA | 109 (15.5) | 2.3 | (1.8 to 2.8) | |
| Bilateral OA | 593 (84.5) | 2.5 | (2.3 to 2.7) | |
| Localisation§ | 0.2 | |||
| Localised OA | 449 (73.0) | 2.3 | (2.1 to 2.5) | |
| Generalised OA | 166 (27.0) | 2.6 | (2.2 to 3.0) | |
| Radiographic severity of OA | ||||
| Kellgren and Lawrence¶ | 0.9 | |||
| Grade 3 | 271 (36.6) | 2.5 | (2.2 to 2.8) | |
| Grade 4 | 470 (63.4) | 2.5 | (2.3 to 2.8) | |
| OA severity (subjective) | ||||
| Intensity of pain (mmVAS), median** | 73 | 0.009 | ||
| ⩽58 | 154 (20.3) | 2.0 | (1.7 to 2.3) | |
| 59–⩽69 | 159 (20.9) | 2.4 | (2.0 to 2.8) | |
| 70–⩽78 | 145 (19.1) | 2.5 | (2.1 to 3.0) | |
| 79–⩽87 | 155 (20.4) | 2.7 | (2.3 to 3.2) | |
| ⩾88 | 147 (19.3) | 3.1 | (2.6 to 3.6) | |
| Additional painful joint regions†† | 0.02 | |||
| None | 175 (22.7) | 2.1 | (1.8 to 2.5) | |
| At least one | 595 (77.3) | 2.6 | (2.4 to 2.9) | |
| WOMAC‡‡ pain (0–20), median 12 | 0.8 | |||
| ⩽9 (least severe) | 147 (23.7) | 2.2 | (1.9 to 2.7) | |
| >9–⩽11 | 131 (21.2) | 2.5 | (2.1 to 3.0) | |
| >11–⩽14 | 207 (33.4) | 2.4 | (2.1 to 2.8) | |
| >14 (most severe) | 134 (21.6) | 2.5 | (2.1 to 3.1) | |
| Walking | 0.3 | |||
| None | 13 (2.1) | 2.1 | (1.2 to 3.8) | |
| Mild | 63 (10.1) | 2.1 | (1.6 to 2.7) | |
| Moderate | 189 (30.3) | 2.2 | (1.9 to 2.6) | |
| Severe | 245 (39.3) | 2.8 | (2.5 to 3.2) | |
| Extreme | 113 (18.1) | 2.2 | (1.7 to 2.7) | |
| Stairs | 0.9 | |||
| None | 6 (1.0) | 5.1 | (1.8 to 15) | |
| Mild | 24 (3.9) | 2.5 | (1.6 to 4.0) | |
| Moderate | 133 (21.3) | 2.4 | (2.0 to 2.9) | |
| Severe | 299 (48.0) | 2.3 | (2.0 to 2.6) | |
| Extreme | 161 (25.8) | 2.7 | (2.3 to 3.1) | |
| Night | 0.9 | |||
| None | 75 (12.1) | 2.3 | (1.8 to 2.9) | |
| Mild | 139 (22.3) | 2.5 | (2.1 to 3.0) | |
| Moderate | 221 (35.5) | 2.4 | (2.1 to 2.8) | |
| Severe | 142 (22.8) | 2.6 | (2.2 to 3.1) | |
| Extreme | 45 (7.2) | 2.1 | (1.5 to 2.8) | |
| Sitting | 0.7 | |||
| None | 73 (11.8) | 2.4 | (1.9 to 3.0) | |
| Mild | 190 (30.6) | 2.3 | (2.0 to 2.7) | |
| Moderate | 237 (38.2) | 2.5 | (2.2 to 2.8) | |
| Severe | 107 (17.2) | 2.5 | (2.1 to 3.2) | |
| Extreme | 14 (2.3) | 1.9 | (1.1 to 3.6) | |
| Standing | 0.6 | |||
| None | 16 (2.6) | 1.9 | (1.0 to 3.5) | |
| Mild | 48 (7.7) | 2.2 | (1.7 to 2.9) | |
| Moderate | 202 (32.5) | 2.5 | (2.2 to 2.9) | |
| Severe | 249 (40.0) | 2.4 | (2.1 to 2.8) | |
| Extreme | 107 (17.2) | 2.4 | (2.0 to 3.0) | |