Characteristics of patients with poly- and dermatomyositis with or without ILD
| Characteristics | ILD present (n = 11) | ILD absent (n = 6) | p Value |
|---|---|---|---|
| *Data available for 10 patients; †data available for eight patients; ‡data available for three patients. | |||
| ILD, interstitial lung disease; PM, polymyositis; DM, dermatomyositis; RF, rheumatoid factor; ANA, antinuclear antibodies; Jo-1, histidyl-tRNA synthetase; CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; VC, vital capacity; TLC, total lung capacity; Tlco, carbon monoxide transfer factor. | |||
| Sex (male/female) | 6/5 | 0/6 | <0.05 |
| Age (years), mean (SD) | 57.5 (10.2) | 58.7 (11.8) | NS |
| Time since onset of PM/DM (months) mean (SD) | 3.3 (3.3) | 9.5 (8.1) | <0.05 |
| PM diagnosis, No (%) | 7 (64) | 2 (33) | NS |
| Symptoms, No (%) | |||
| Arthritis | 5 (45) | 0 (0) | <0.05 |
| Cough | 5 (45) | 1 (17) | NS |
| Dyspnoea | 6 (55) | 4 (67) | NS |
| Cough or dyspnoea | 8 (73) | 4 (67) | NS |
| Raynaud’s phenomenon | 2 (18) | 1 (17) | NS |
| Dysphagia | 3 (27) | 2 (33) | NS |
| Swollen hands | 3 (27) | 0 (0) | NS |
| Laboratory tests, No (%) | |||
| RF | 6 (55) | 1 (17) | NS |
| ANA | 4 (36) | 5 (83) | NS |
| Anti-Ro/SSA | 5 (45) | 1 (17) | NS |
| Anti-Jo-1 | 4 (36) | 0 (0) | <0.05 |
| Raised CK | 11 (100) | 6 (100) | NS |
| Raised ALT | 8 (80)* | 4 (67) | NS |
| Raised AST | 11 (100)* | 6 (100) | NS |
| Lung function (% predicted) mean (SD) | |||
| VC | 74.6 (16.9)† | 106.0 (25.1)‡ | <0.05 |
| TLC | 77.4 (18.2)† | 110.7 (20.2)‡ | <0.05 |
| Tlco | 62.4 (7.0)† | 63.0 (16.7)‡ | NS |