Results of ANA and anti-dsDNA testing by various methods grouped according to disease classification in a randomly collected cohort of ANA positive subjects. Figures represent mean values (SD) unless otherwise indicated
| Diagnostic group(n) | ANA | ssDNA ELISA | dsDNA ELISA | EliA | CLIFT | ||||
|---|---|---|---|---|---|---|---|---|---|
| OD ratio* (SD) | Positive No (%) | Units (SD) | Positive No (%) | Units (SD) | Positive No (%) | Units (SD) | Positive No (%) | Titre (SD) | |
| n, number of patients in each diagnostic group. | |||||||||
| *Ratio of the OD in ELISA obtained with patient serum and the OD of a weakly positive reference ANA antibody. For cut off values and analytical details, see “Materials and methods”. | |||||||||
| VORD, various other rheumatic diseases. | |||||||||
| SLE (39) | 4.4 (1.6) | 32 (82) | 171 (48) | 31 (79) | 171 (51) | 17 (44) | 138 (196) | 16 (41) | 159 (212) |
| SS (25) | 5.3 (1.8) | 10 (40) | 143 (61) | 4 (16) | 164 (70) | 3 (12) | 89 (56) | 1 (4) | 80 (−) |
| RA (17) | 4 (1.1) | 8 (47) | 165 (51) | 5 (29) | 200 (0) | 1 (6) | 48 (−) | 0 | − |
| UCTD (9) | 3.6 (1.7) | 2 (22) | 120 (21) | 2 (22) | 194 (8) | 2 (22) | 59 (0.2) | 0 | − |
| VORD (9) | 4.6 (1.9) | 3 (33) | 141 (87) | 2 (22) | 127 (88) | 0 | − | 0 | − |
| Normal subjects (59) | 3.9 (1.7) | 24 (41) | 145 (60) | 18 (31) | 146 (53) | 13 (22) | 46 (49) | 0 | − |