Modified Sharp progression rate (points per year) after 2 years, 4 years, and from 1 to 4 years in the delayed and early treatment groups, stratified by diagnosis of definite versus probable RA and by Sharp score at baseline (Leiden EAC study)
| Subgroup | Delayed treatment group | Early treatment group | ||||||
|---|---|---|---|---|---|---|---|---|
| No of patients | Change 0–2 years | Change 0–4 years | Change 1–4 years | No of patients | Change 0–2 years | Change 0–4 years | Change 1–4 years | |
| Values are the median (25th–75th centile). | ||||||||
| *p<0.05 in the delayed treatment group versus those in the early treatment group. | ||||||||
| Diagnosis at baseline | ||||||||
| Definite RA | 52 | 6.1 (1.7, 16.8)* | 3.1 (0.8, 7.2)* | 1.0 (0, 8.4) | 51 | 1.6 (0, 10.8) | 1.8 (0.2, 4.4) | 0.6 (0, 3.4) |
| Probable RA | 25 | 1.9 (0, 2.4)* | 0.8 (0.5, 4.8) | 0.7 (0, 3.6) | 24 | 0.0 (0, 2.4) | 0.6 (0, 4.9) | 0.8 (0, 7.3) |
| Sharp score at baseline | ||||||||
| 0 | 37 | 1.6 (0, 6.5) | 1.0 (0, 6.8) | 0.8 (0, 6.1) | 31 | 1.0 (0, 4.7) | 1.8 (0.4, 5.6) | 2.0 (0, 6.0) |
| >0 | 36 | 7.2 (3.0, 15.0)* | 3.0 (1.4, 6)* | 0.8 (0, 3.4) | 39 | 1.0 (0, 7.7) | 1.1 (0, 3.4) | 0.5 (0, 3.1) |