Table 4

Patients with a change >SDD from baseline in erosion (SDD = 7.4) and joint space narrowing (SDD = 6.1) scores of the hands and feet at week 102

Assessment variableMTX-only3 mg/kg Infliximab+MTX10 mg/kg Infliximab+MTXTotal Infliximab
q 8 Weeksq 4 Weeksq 8 Weeksq 4 Weeks
Results are shown as No (%) of patients.
Patients with early RA17191920765
Patients evaluated12101617649
Erosions SDD = 7.4
Total erosion score7 (58)0 (0)0 (0)0 (0)0 (0)0 (0)
    p Value v placebo0.005<0.001<0.0010.038<0.001
Hands6 (50)0 (0)1 (6)1 (6)0 (0)2 (4)
    p Value v placebo0.0150.0230.0110.054<0.001
Feet3 (25)0 (0)0 (0)0 (0)0 (0)0 (0)
    p Value v placebo0.2210.0670.0600.5150.006
Joint space narrowing (JSN) SDD = 6.1
Total JSN score6 (50)1 (10.0)0 (0)1 (6)0 (0)2 (4)
    p Value v placebo0.0740.0020.0110.54<0.001
Hands4 (33)1 (10.0)0 (0)1 (6)0 (0)2 (4)
    p Value v placebo0.3230.0240.1300.2450.011
Feet7 (58)0 (0.00)0 (0)1 (6)0 (0)1 (2)
    p Value v placebo0.005<0.0010.0030.038